| pubmed-article:10802653 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10802653 | lifeskim:mentions | umls-concept:C0282641 | lld:lifeskim |
| pubmed-article:10802653 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10802653 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:10802653 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10802653 | lifeskim:mentions | umls-concept:C0600205 | lld:lifeskim |
| pubmed-article:10802653 | lifeskim:mentions | umls-concept:C1158478 | lld:lifeskim |
| pubmed-article:10802653 | lifeskim:mentions | umls-concept:C1705422 | lld:lifeskim |
| pubmed-article:10802653 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:10802653 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10802653 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10802653 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10802653 | pubmed:dateCreated | 2000-6-12 | lld:pubmed |
| pubmed-article:10802653 | pubmed:abstractText | The development of non-viral gene-transfer technologies that can support stable chromosomal integration and persistent gene expression in vivo is desirable. Here we describe the successful use of transposon technology for the nonhomologous insertion of foreign genes into the genomes of adult mammals using naked DNA. We show that the Sleeping Beauty transposase can efficiently insert transposon DNA into the mouse genome in approximately 5-6% of transfected mouse liver cells. Chromosomal transposition resulted in long-term expression (>5 months) of human blood coagulation factor IX at levels that were therapeutic in a mouse model of haemophilia B. Our results establish DNA-mediated transposition as a new genetic tool for mammals, and provide new strategies to improve existing non-viral and viral vectors for human gene therapy applications. | lld:pubmed |
| pubmed-article:10802653 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10802653 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10802653 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10802653 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10802653 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10802653 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10802653 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10802653 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10802653 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10802653 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10802653 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10802653 | pubmed:month | May | lld:pubmed |
| pubmed-article:10802653 | pubmed:issn | 1061-4036 | lld:pubmed |
| pubmed-article:10802653 | pubmed:author | pubmed-author:ChinLL | lld:pubmed |
| pubmed-article:10802653 | pubmed:author | pubmed-author:KayM AMA | lld:pubmed |
| pubmed-article:10802653 | pubmed:author | pubmed-author:IvicsZZ | lld:pubmed |
| pubmed-article:10802653 | pubmed:author | pubmed-author:YangS WSW | lld:pubmed |
| pubmed-article:10802653 | pubmed:author | pubmed-author:MeuseLL | lld:pubmed |
| pubmed-article:10802653 | pubmed:author | pubmed-author:IzsvakZZ | lld:pubmed |
| pubmed-article:10802653 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10802653 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:10802653 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10802653 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10802653 | pubmed:pagination | 35-41 | lld:pubmed |
| pubmed-article:10802653 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:meshHeading | pubmed-meshheading:10802653... | lld:pubmed |
| pubmed-article:10802653 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10802653 | pubmed:articleTitle | Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system. | lld:pubmed |
| pubmed-article:10802653 | pubmed:affiliation | Departments of Pediatrics and Genetics, Stanford University School of Medicine, Stanford, California, USA. | lld:pubmed |
| pubmed-article:10802653 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10802653 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:14071 | entrezgene:pubmed | pubmed-article:10802653 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10802653 | lld:pubmed |
