| pubmed-article:10798717 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10798717 | lifeskim:mentions | umls-concept:C0003402 | lld:lifeskim |
| pubmed-article:10798717 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:10798717 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:10798717 | lifeskim:mentions | umls-concept:C0377952 | lld:lifeskim |
| pubmed-article:10798717 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10798717 | pubmed:dateCreated | 2000-6-29 | lld:pubmed |
| pubmed-article:10798717 | pubmed:abstractText | 4-Mercaptoimidazoles derived from the naturally occurring family of antioxidants, the ovothiols, were assayed for their antioxidant properties. These compounds are powerful HOCl scavengers, more potent than the aliphatic thiol N-acetylcysteine. They react slowly with hydrogen peroxide with second order rate constants of 0.13-0.89 M(-1)s(-1). Scavenging of hydroxyl radical occurs at a diffusion-controlled rate (k=2.0-5.0 x 10(10)M(-1)s(-1)) for the most active compounds, which are also able to inhibit copper-induced LDL peroxidation. The combination of radical scavenging and copper chelating properties may explain the inhibitory effects on LDL peroxidation. Two molecules of mercaptoimidazole can chelate a copper ion and form a square planar complex detected by EPR. Compounds bearing an electron-withdrawing group on position 2 of the imidazole ring are the most potent antioxidant molecules in this series. | lld:pubmed |
| pubmed-article:10798717 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10798717 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10798717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10798717 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10798717 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10798717 | pubmed:issn | 1071-5762 | lld:pubmed |
| pubmed-article:10798717 | pubmed:author | pubmed-author:FruchartJ CJC | lld:pubmed |
| pubmed-article:10798717 | pubmed:author | pubmed-author:CatteauJ PJP | lld:pubmed |
| pubmed-article:10798717 | pubmed:author | pubmed-author:BernierJ LJL | lld:pubmed |
| pubmed-article:10798717 | pubmed:author | pubmed-author:DuriezPP | lld:pubmed |
| pubmed-article:10798717 | pubmed:author | pubmed-author:BaillyFF | lld:pubmed |
| pubmed-article:10798717 | pubmed:author | pubmed-author:TeissierEE | lld:pubmed |
| pubmed-article:10798717 | pubmed:author | pubmed-author:VezinHH | lld:pubmed |
| pubmed-article:10798717 | pubmed:author | pubmed-author:ZoeteVV | lld:pubmed |
| pubmed-article:10798717 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10798717 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:10798717 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10798717 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10798717 | pubmed:pagination | 515-24 | lld:pubmed |
| pubmed-article:10798717 | pubmed:dateRevised | 2000-12-18 | lld:pubmed |
| pubmed-article:10798717 | pubmed:meshHeading | pubmed-meshheading:10798717... | lld:pubmed |
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| pubmed-article:10798717 | pubmed:meshHeading | pubmed-meshheading:10798717... | lld:pubmed |
| pubmed-article:10798717 | pubmed:meshHeading | pubmed-meshheading:10798717... | lld:pubmed |
| pubmed-article:10798717 | pubmed:meshHeading | pubmed-meshheading:10798717... | lld:pubmed |
| pubmed-article:10798717 | pubmed:meshHeading | pubmed-meshheading:10798717... | lld:pubmed |
| pubmed-article:10798717 | pubmed:meshHeading | pubmed-meshheading:10798717... | lld:pubmed |
| pubmed-article:10798717 | pubmed:meshHeading | pubmed-meshheading:10798717... | lld:pubmed |
| pubmed-article:10798717 | pubmed:meshHeading | pubmed-meshheading:10798717... | lld:pubmed |
| pubmed-article:10798717 | pubmed:meshHeading | pubmed-meshheading:10798717... | lld:pubmed |
| pubmed-article:10798717 | pubmed:meshHeading | pubmed-meshheading:10798717... | lld:pubmed |
| pubmed-article:10798717 | pubmed:meshHeading | pubmed-meshheading:10798717... | lld:pubmed |
| pubmed-article:10798717 | pubmed:meshHeading | pubmed-meshheading:10798717... | lld:pubmed |
| pubmed-article:10798717 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10798717 | pubmed:articleTitle | 4-Mercaptoimidazoles derived from the naturally occurring antioxidant ovothiols 1. Antioxidant properties. | lld:pubmed |
| pubmed-article:10798717 | pubmed:affiliation | Laboratoire de Chimie Organique Physique associée à l'Ecole Nationale Supérieure de Chimie de Lille, ESA CNRS 8009, Villeneuve d'Ascq, France. | lld:pubmed |
| pubmed-article:10798717 | pubmed:publicationType | Journal Article | lld:pubmed |
