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pubmed-article:10795736pubmed:abstractTextWe undertook a kinetic analysis of the generation of mature T cells in TCR and coreceptor transgenic mice using BrdU labeling. We observed that the selection efficiency of mature CD4-CD8+ and CD4+CD8- thymocytes could be as high as 40% and 90% of CD4+CD8+ precursors, respectively. The surprisingly high efficiency of selection favors an instructional model of lineage commitment and is incompatible with a stochastic model in which the efficiency of selection would be no greater than 100% in both lineages combined.lld:pubmed
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pubmed-article:10795736pubmed:articleTitleHighly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment.lld:pubmed
pubmed-article:10795736pubmed:affiliationDepartment of Molecular and Cell Biology, University of California, Berkeley 94720, USA.lld:pubmed
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pubmed-article:10795736pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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