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pubmed-article:10795415pubmed:abstractTextZopiclone (Zimovane) is a cyclopyrrolone compound which exhibits hypnotic and sedative effects while also exhibiting anticonvulsant and muscle relaxant activities. The detection and quantification of zopiclone is difficult. It has a high molecular weight compared to most other commonly used drugs, therapeutic levels are not high, and it is unstable in nucleophilic solvents. A degradation product of zopiclone, 2-amino-5-chloropyridine (ACP) together with a method for its detection using high-performance liquid chromatography with diode array detection has been described previously. An account is presented of a simple method for the detection of ACP using gas chromatography with mass selective detection (GC/MS) which will facilitate detection of zopiclone use as part of a routine screen.lld:pubmed
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pubmed-article:10795415pubmed:authorpubmed-author:ForrestA RARlld:pubmed
pubmed-article:10795415pubmed:authorpubmed-author:GallowayJ HJHlld:pubmed
pubmed-article:10795415pubmed:authorpubmed-author:MarshI DIDlld:pubmed
pubmed-article:10795415pubmed:authorpubmed-author:NewtonC MCMlld:pubmed
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pubmed-article:10795415pubmed:volume39lld:pubmed
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pubmed-article:10795415pubmed:pagination253-6lld:pubmed
pubmed-article:10795415pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:10795415pubmed:articleTitleA method for the rapid detection of the zopiclone degradation product 2-amino-5-chloropyridine.lld:pubmed
pubmed-article:10795415pubmed:affiliationDepartment of Clinical Chemistry, Royal Hallamshire Hospital, Sheffield, United Kingdom.lld:pubmed
pubmed-article:10795415pubmed:publicationTypeJournal Articlelld:pubmed