| pubmed-article:10786665 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10786665 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:10786665 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
| pubmed-article:10786665 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:10786665 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:10786665 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10786665 | lifeskim:mentions | umls-concept:C0061179 | lld:lifeskim |
| pubmed-article:10786665 | lifeskim:mentions | umls-concept:C0596448 | lld:lifeskim |
| pubmed-article:10786665 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:10786665 | pubmed:dateCreated | 2000-5-11 | lld:pubmed |
| pubmed-article:10786665 | pubmed:abstractText | Geldanamycin (GM) is a natural antibiotic that binds Hsp90 and induces the degradation of receptor tyrosine kinases, steroid receptors, and Raf. It is a potent inhibitor of cancer cells that overexpress HER-kinases, but its effects on other important proteins may cause significant toxicity and limit its clinical use. We report the synthesis and identification of a GM dimer, GMD-4c, which had selective activity against HER-kinases. Selectivity was a function of linker length and required two intact GM moieties. GMD-4c is a potent inducer of G1 block and apoptosis of breast cancer cell lines that overexpress HER2, but does not appreciably inhibit the growth of 32D cells that lack HER-kinases. GMD-4c could be useful in the treatment of carcinomas dependent on HER-kinases. | lld:pubmed |
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| pubmed-article:10786665 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10786665 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10786665 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10786665 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10786665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10786665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10786665 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10786665 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10786665 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:10786665 | pubmed:author | pubmed-author:RosenNN | lld:pubmed |
| pubmed-article:10786665 | pubmed:author | pubmed-author:Sepp-Lorenzin... | lld:pubmed |
| pubmed-article:10786665 | pubmed:author | pubmed-author:DanishefskyS... | lld:pubmed |
| pubmed-article:10786665 | pubmed:author | pubmed-author:MünsterP NPN | lld:pubmed |
| pubmed-article:10786665 | pubmed:author | pubmed-author:KudukS DSD | lld:pubmed |
| pubmed-article:10786665 | pubmed:author | pubmed-author:ZhengF FFF | lld:pubmed |
| pubmed-article:10786665 | pubmed:author | pubmed-author:ChiosisGG | lld:pubmed |
| pubmed-article:10786665 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10786665 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10786665 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:10786665 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10786665 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10786665 | pubmed:pagination | 2090-4 | lld:pubmed |
| pubmed-article:10786665 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10786665 | pubmed:meshHeading | pubmed-meshheading:10786665... | lld:pubmed |
| pubmed-article:10786665 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10786665 | pubmed:articleTitle | Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases. | lld:pubmed |
| pubmed-article:10786665 | pubmed:affiliation | Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. zhengf@mskcc.org | lld:pubmed |
| pubmed-article:10786665 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10786665 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10786665 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10786665 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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