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pubmed-article:10785238pubmed:abstractTextOBJECTIVE: To study whether minimal interference in the process of selection of the single dominant follicle may serve as the basis for a simplified ovarian stimulation regimen for IVF. DESIGN: Single-center randomized pilot study. SETTING: Tertiary referral fertility center. PATIENT(s): Fifteen normo-ovulatory patients with a regular indication for IVF. INTERVENTION(s): Ovarian stimulation for IVF was begun with 100 or 150 IU/d recombinant FSH starting on cycle day 5. From cycle day 8 or later, cotreatment was begun with 0.25 mg/d GnRH antagonist. No luteal support was provided. MAIN OUTCOME MEASURE(s): Total number of dominant follicles and characteristics of the endocrine cycle. RESULT(s): Multiple follicle development occurred in five of eight patients in the 100-IU group and in all seven women in the 150-IU group. Follicular phase and luteal phase lengths were normal, but the endocrine profile was abnormal. CONCLUSION(s): A fixed daily dose of 150 IU recombinant FSH starting in the midfollicular phase resulted in ongoing growth of a restricted number of dominant follicles and sufficient oocytes retrieved to lead to ET. A marked reduction in the total amount of gonadotropins administered compared with standard treatment was achieved. Withholding luteal support did not exclude pregnancies.lld:pubmed
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pubmed-article:10785238pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10785238pubmed:articleTitleA pilot study involving minimal ovarian stimulation for in vitro fertilization: extending the "follicle-stimulating hormone window" combined with the gonadotropin-releasing hormone antagonist cetrorelix.lld:pubmed
pubmed-article:10785238pubmed:affiliationDivision of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.lld:pubmed
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pubmed-article:10785238pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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