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| pubmed-article:10783389 | lifeskim:mentions | umls-concept:C0242299 | lld:lifeskim |
| pubmed-article:10783389 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:10783389 | lifeskim:mentions | umls-concept:C0682972 | lld:lifeskim |
| pubmed-article:10783389 | lifeskim:mentions | umls-concept:C0068605 | lld:lifeskim |
| pubmed-article:10783389 | lifeskim:mentions | umls-concept:C1538474 | lld:lifeskim |
| pubmed-article:10783389 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:10783389 | pubmed:issue | 28 | lld:pubmed |
| pubmed-article:10783389 | pubmed:dateCreated | 2000-8-16 | lld:pubmed |
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| pubmed-article:10783389 | pubmed:abstractText | Neuromedin U is a bioactive peptide first isolated from porcine spinal cord. In this paper, we demonstrate that neuromedin U is the cognate ligand for the orphan G protein-coupled receptor, FM-3, isolated originally as a homologue of neurotensin and growth hormone secretogogue receptors. Neuromedin U induced specific and evident elevation of extracellular acidification rates, arachidonic acid metabolite release, and intracellular Ca(2+) mobilization in Chinese hamster ovary cells expressing human FM-3. In addition, radiolabeled neuromedin U specifically bound to membrane fractions prepared from these cells with high affinity. We subsequently analyzed the tissue distribution of neuromedin U and FM-3 mRNAs in rats using quantitative reverse transcription-polymerase chain reaction. Neuromedin U mRNA was highly expressed in the gastrointestinal tract, and the highest expression was detected in the pituitary gland. On the other hand, FM-3 mRNA was highly expressed in the small intestine and lung, suggesting that neuromedin U plays important roles in these tissues. The identification of a specific and functional receptor for neuromedin U will facilitate studies on their physiological roles and the search for receptor agonists and antagonists. | lld:pubmed |
| pubmed-article:10783389 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10783389 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10783389 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10783389 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10783389 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10783389 | pubmed:author | pubmed-author:FujiiRR | lld:pubmed |
| pubmed-article:10783389 | pubmed:author | pubmed-author:NEELH BHB | lld:pubmed |
| pubmed-article:10783389 | pubmed:author | pubmed-author:HinumaSS | lld:pubmed |
| pubmed-article:10783389 | pubmed:author | pubmed-author:FujinoMM | lld:pubmed |
| pubmed-article:10783389 | pubmed:author | pubmed-author:NishimuraOO | lld:pubmed |
| pubmed-article:10783389 | pubmed:author | pubmed-author:KawamataYY | lld:pubmed |
| pubmed-article:10783389 | pubmed:author | pubmed-author:HosoyaMM | lld:pubmed |
| pubmed-article:10783389 | pubmed:author | pubmed-author:HabataYY | lld:pubmed |
| pubmed-article:10783389 | pubmed:author | pubmed-author:FukusumiSS | lld:pubmed |
| pubmed-article:10783389 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10783389 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:10783389 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:10783389 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10783389 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10783389 | pubmed:pagination | 21068-74 | lld:pubmed |
| pubmed-article:10783389 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:10783389 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10783389 | pubmed:articleTitle | Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. | lld:pubmed |
| pubmed-article:10783389 | pubmed:affiliation | Discovery Research Laboratories I, Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd., Tsukuba, Ibaraki 300-4293, Japan. | lld:pubmed |
| pubmed-article:10783389 | pubmed:publicationType | Journal Article | lld:pubmed |
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