| pubmed-article:10779342 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10779342 | lifeskim:mentions | umls-concept:C0598175 | lld:lifeskim |
| pubmed-article:10779342 | lifeskim:mentions | umls-concept:C0080113 | lld:lifeskim |
| pubmed-article:10779342 | lifeskim:mentions | umls-concept:C0680011 | lld:lifeskim |
| pubmed-article:10779342 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:10779342 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:10779342 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:10779342 | pubmed:dateCreated | 2000-5-18 | lld:pubmed |
| pubmed-article:10779342 | pubmed:abstractText | Retinoblastoma protein (Rb) plays important roles in cell cycle progression and cellular differentiation. It may also participate in M phase events, although heretofore only circumstantial evidence has suggested such involvement. Here we show that Rb interacts, through an IxCxE motif and specifically during G(2)/M phase, with hsHec1p, a protein essential for proper chromosome segregation. The interaction between Rb and hsHec1p was reconstituted in a yeast strain in which human hsHEC1 rescues the null mutation of scHEC1. Expression of Rb reduced chromosome segregation errors fivefold in yeast cells sustained by a temperature-sensitive (ts) hshec1-113 allele and enhanced the ability of wild-type hsHec1p to suppress lethality caused by a ts smc1 mutation. The interaction between Hec1p and Smc1p was important for the specific DNA-binding activity of Smc1p. Expression of Rb restored part of the inactivated function of hshec1-113p and thereby increased the DNA-binding activity of Smc1p. Rb thus increased the fidelity of chromosome segregation mediated by hsHec1p in a heterologous yeast system. | lld:pubmed |
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| pubmed-article:10779342 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10779342 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10779342 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10779342 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10779342 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10779342 | pubmed:month | May | lld:pubmed |
| pubmed-article:10779342 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:10779342 | pubmed:author | pubmed-author:RileyD JDJ | lld:pubmed |
| pubmed-article:10779342 | pubmed:author | pubmed-author:ChenYY | lld:pubmed |
| pubmed-article:10779342 | pubmed:author | pubmed-author:ChenP LPL | lld:pubmed |
| pubmed-article:10779342 | pubmed:author | pubmed-author:LeeW HWH | lld:pubmed |
| pubmed-article:10779342 | pubmed:author | pubmed-author:ZhengLL | lld:pubmed |
| pubmed-article:10779342 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10779342 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:10779342 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10779342 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10779342 | pubmed:pagination | 3529-37 | lld:pubmed |
| pubmed-article:10779342 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10779342 | pubmed:meshHeading | pubmed-meshheading:10779342... | lld:pubmed |
| pubmed-article:10779342 | pubmed:meshHeading | pubmed-meshheading:10779342... | lld:pubmed |
| pubmed-article:10779342 | pubmed:meshHeading | pubmed-meshheading:10779342... | lld:pubmed |
| pubmed-article:10779342 | pubmed:meshHeading | pubmed-meshheading:10779342... | lld:pubmed |
