| pubmed-article:10767627 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10767627 | lifeskim:mentions | umls-concept:C0206745 | lld:lifeskim |
| pubmed-article:10767627 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:10767627 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10767627 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10767627 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10767627 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10767627 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:10767627 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:10767627 | pubmed:dateCreated | 2000-6-16 | lld:pubmed |
| pubmed-article:10767627 | pubmed:abstractText | Gene-disruption studies involving poly(ADP-ribose) polymerase (Parp) have identified the various roles of Parp in cellular responses to DNA damage. The partial rescue of V[D]J recombination process in SCID/Parp(-/-) double mutant mice indicates the participation of Parp in the repair of DNA strand break. Parp(-/-) mice are more sensitive to the lethal effects of alkylating agents. Parp is also thought to be involved in base-excision repair after DNA damage caused by alkylating agents. On the other hand, resistance of Parp(-/-) mice to DNA damage induced by reactive oxygen species implicates the contribution of Parp to cell death through NAD depletion. Parp(-/-) mice with two different genetic backgrounds also show enhanced sensitivity to the lethal effects of gamma-irradiation. Parp(-/-) mice show more severe villous atrophy of the small intestine compared to the wild-type counterpart in a genetic background of 129Sv/C57BL6. Other forms of enhanced tissue damage have been identified in Parp(-/-) mice with a genetic background of 129Sv/ICR. For example, Parp(-/-) mice exhibit extensive hemorrhage in the glandular stomach and other tissues, such as the testes, after gamma-irradiation. Severe myelosuppression is also observed in both Parp(+/+) and Parp(-/-) mice, but Parp(+/+) mice show extensive extramedullary hematopoiesis in the spleen during the recovery phase of post-irradiation, whereas the spleen of Parp(-/-) mice exhibits severe atrophy with no extramedullary hematopoiesis. The absence of extramedullary hematopoiesis in the spleen is probably the underlying mechanism of hemorrhagic tendency in various tissues of Parp(-/-) mice. These findings suggest that loss of Parp activity could contribute to post-irradiation tissue hemorrhage. | lld:pubmed |
| pubmed-article:10767627 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10767627 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10767627 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10767627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10767627 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10767627 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10767627 | pubmed:issn | 0027-5107 | lld:pubmed |
| pubmed-article:10767627 | pubmed:author | pubmed-author:SugimuraTT | lld:pubmed |
| pubmed-article:10767627 | pubmed:author | pubmed-author:SuzukiHH | lld:pubmed |
| pubmed-article:10767627 | pubmed:author | pubmed-author:NakamotoKK | lld:pubmed |
| pubmed-article:10767627 | pubmed:author | pubmed-author:TsutsumiMM | lld:pubmed |
| pubmed-article:10767627 | pubmed:author | pubmed-author:MasutaniMM | lld:pubmed |
| pubmed-article:10767627 | pubmed:author | pubmed-author:NozakiTT | lld:pubmed |
| pubmed-article:10767627 | pubmed:author | pubmed-author:NakagamaHH | lld:pubmed |
| pubmed-article:10767627 | pubmed:author | pubmed-author:KusuokaOO | lld:pubmed |
| pubmed-article:10767627 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10767627 | pubmed:volume | 462 | lld:pubmed |
| pubmed-article:10767627 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10767627 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10767627 | pubmed:pagination | 159-66 | lld:pubmed |
| pubmed-article:10767627 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10767627 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10767627 | pubmed:articleTitle | The response of Parp knockout mice against DNA damaging agents. | lld:pubmed |
| pubmed-article:10767627 | pubmed:affiliation | Biochemistry Division, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo, 104-0045, Japan. mmasutan@gan2.ncc.go.jp | lld:pubmed |
| pubmed-article:10767627 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10767627 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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