| pubmed-article:10766979 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10766979 | lifeskim:mentions | umls-concept:C0032914 | lld:lifeskim |
| pubmed-article:10766979 | lifeskim:mentions | umls-concept:C0340274 | lld:lifeskim |
| pubmed-article:10766979 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10766979 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:10766979 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10766979 | pubmed:dateCreated | 2000-6-8 | lld:pubmed |
| pubmed-article:10766979 | pubmed:abstractText | Genetic factors are known to be important in the etiology of pre-eclampsia and possibly also gestational hypertension, but the degree of genetic influence has not been quantified. To estimate the genetic and environmental effects on the liability of developing pre-eclampsia and gestational hypertension, we cross-linked the population-based Swedish Twin Register and the Swedish Medical Birth Register. We included female twin pairs with known zygosity, both of whom gave birth in Sweden from 1973 through 1993; in all 917 monozygotic and 1,199 dizygotic twin pairs. For pre-eclampsia, the estimates of heritability and nonshared environmental effect were 0. 54 (95% confidence interval 0-0.71) and 0.46 (0.29-0.67), respectively; corresponding estimates for gestational hypertension were 0.24 (0-0.53) and 0.76 (0.47-1.00), respectively. When considering both diseases as a single entity (pregnancy-induced hypertensive diseases), the heritability estimate was 0.47 (0.13-0. 61). These results suggest that genetic factors are important in the development of pre-eclampsia as well as gestational hypertension. The heritability estimates can be of importance when planning genetic linkage studies. In efforts to identify women with elevated risk of developing pre-eclampsia during pregnancy, a question about family history of pre-eclampsia should be included. | lld:pubmed |
| pubmed-article:10766979 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10766979 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10766979 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10766979 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10766979 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10766979 | pubmed:issn | 0148-7299 | lld:pubmed |
| pubmed-article:10766979 | pubmed:author | pubmed-author:LipworthLL | lld:pubmed |
| pubmed-article:10766979 | pubmed:author | pubmed-author:CnattingiusSS | lld:pubmed |
| pubmed-article:10766979 | pubmed:author | pubmed-author:LichtensteinP... | lld:pubmed |
| pubmed-article:10766979 | pubmed:author | pubmed-author:Salonen RosHH | lld:pubmed |
| pubmed-article:10766979 | pubmed:copyrightInfo | Copyright 2000 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:10766979 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10766979 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:10766979 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:10766979 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10766979 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10766979 | pubmed:pagination | 256-60 | lld:pubmed |
| pubmed-article:10766979 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10766979 | pubmed:meshHeading | pubmed-meshheading:10766979... | lld:pubmed |
| pubmed-article:10766979 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10766979 | pubmed:articleTitle | Genetic effects on the liability of developing pre-eclampsia and gestational hypertension. | lld:pubmed |
| pubmed-article:10766979 | pubmed:affiliation | Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden. Helena.Ros@mep.ki.se | lld:pubmed |
| pubmed-article:10766979 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10766979 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10766979 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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