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pubmed-article:10762211pubmed:abstractTextRecently, we have developed a simple and reliable method to efficiently isolate large numbers of neonatal porcine islets (NPI). We and others have shown that NPI are susceptible to cytolysis by the activation of human complement in vitro. Microencapsulation of islets may be one strategy to protect NPI from this form of rejection. We examined whether microencapsulation can prevent lysis of NPI induced by human antibody and complement in vitro and also assessed their ability to reverse hyperglycemia in diabetic nude mice.lld:pubmed
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pubmed-article:10762211pubmed:articleTitleMicroencapsulation of neonatal porcine islets: protection from human antibody/complement-mediated cytolysis in vitro and long-term reversal of diabetes in nude mice.lld:pubmed
pubmed-article:10762211pubmed:affiliationSurgical-Medical Research Institute, Department of Surgery, University of Alberta, Edmonton, Canada.lld:pubmed
pubmed-article:10762211pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10762211pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed