| pubmed-article:10756023 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10756023 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:10756023 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10756023 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:10756023 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:10756023 | lifeskim:mentions | umls-concept:C0083001 | lld:lifeskim |
| pubmed-article:10756023 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10756023 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:10756023 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:10756023 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:10756023 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10756023 | pubmed:dateCreated | 2000-5-18 | lld:pubmed |
| pubmed-article:10756023 | pubmed:abstractText | Increased kynurenine pathway metabolism has been implicated in the etiology of AIDS dementia complex (ADC). The rate-limiting enzyme for this pathway is indolamine 2,3-dioxygenase (IDO). We tested the efficacy of different strains of human immunodeficiency virus type 1 (HIV1-BaL, HIV1-JRFL, and HIV1-631) to induce IDO in cultured human monocyte-derived macrophages (MDM). A significant increase in both IDO protein and kynurenine synthesis was observed after 48 h in MDM infected with the brain-derived HIV-1 isolates, laboratory-adapted (LA) HIV1-JRFL, and primary isolate HIV1-631. In contrast, almost no kynurenine production or IDO protein was evident in MDM infected with the highly replicating macrophage-tropic LA strain HIV1-BaL. The induction of IDO and kynurenine synthesis by HIV1-JRFL and HIV1-631 declined to baseline levels by day 8 postinfection. Abundant HIV-1 replication did not reduce the ability of exogenous gamma interferon (IFN-gamma) to induce IDO and kynurenine synthesis in HIV-infected MDM. The addition of anti-IFN-gamma antibody to MDM infected with HIV1-JRFL resulted in an absence of detectable IDO protein after 48 h and a decrease of 64% +/- 1% in supernatant kynurenine concentration. Together, these results indicate that only selected strains of HIV-1 are capable of inducing IDO synthesis and subsequent kynurenine metabolism in MDM. The induction of IDO, while apparently independent of replication capacity, appears to be mediated by a transient production of IFN-gamma in MDM responding to the initial infection with selected strains of HIV-1. | lld:pubmed |
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| pubmed-article:10756023 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10756023 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10756023 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10756023 | pubmed:month | May | lld:pubmed |
| pubmed-article:10756023 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:10756023 | pubmed:author | pubmed-author:KapoorVV | lld:pubmed |
| pubmed-article:10756023 | pubmed:author | pubmed-author:NashTT | lld:pubmed |
| pubmed-article:10756023 | pubmed:author | pubmed-author:NaikMM | lld:pubmed |
| pubmed-article:10756023 | pubmed:author | pubmed-author:TakikawaOO | lld:pubmed |
| pubmed-article:10756023 | pubmed:author | pubmed-author:GrantR SRS | lld:pubmed |
| pubmed-article:10756023 | pubmed:author | pubmed-author:LittlejohnTT | lld:pubmed |
| pubmed-article:10756023 | pubmed:author | pubmed-author:ThuruthyilS... | lld:pubmed |
| pubmed-article:10756023 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10756023 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:10756023 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10756023 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10756023 | pubmed:pagination | 4110-5 | lld:pubmed |
| pubmed-article:10756023 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10756023 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10756023 | pubmed:articleTitle | Induction of indolamine 2,3-dioxygenase in primary human macrophages by human immunodeficiency virus type 1 is strain dependent. | lld:pubmed |
| pubmed-article:10756023 | pubmed:affiliation | School of Physiology and Pharmacology, Faculty of Medicine, University of New South Wales, Sydney 2052, Australia. | lld:pubmed |
| pubmed-article:10756023 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10756023 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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