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| pubmed-article:10755614 | lifeskim:mentions | umls-concept:C0037039 | lld:lifeskim |
| pubmed-article:10755614 | lifeskim:mentions | umls-concept:C0163611 | lld:lifeskim |
| pubmed-article:10755614 | lifeskim:mentions | umls-concept:C1518516 | lld:lifeskim |
| pubmed-article:10755614 | lifeskim:mentions | umls-concept:C1326230 | lld:lifeskim |
| pubmed-article:10755614 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:10755614 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:10755614 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10755614 | pubmed:dateCreated | 2000-4-26 | lld:pubmed |
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| pubmed-article:10755614 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10755614 | pubmed:abstractText | T lymphocyte activation evokes distinct changes in cell surface O-glycans. CD8+ T cells undergo an elimination of sialic acid on core 1 O-glycans and an induction of core 2 O-glycans until either apoptotic death or differentiation into memory cells. We find that the ST3Gal-I sialyltransferase is required for core 1 O-glycan sialylation and its deficiency induces core 2 O-glycan biosynthesis. Apoptosis ensues with the loss of peripheral CD8+ T cells in the absence of immune stimulation. Cell surface ligation of the ST3Gal-I substrate CD43 recapitulates this phenotype by a caspase 3-independent mechanism. Control of core 1 O-glycan sialylation in T lymphocytes by ST3Gal-I comprises a homeostatic mechanism that eliminates CD8+ T cells by apoptosis while facilitating the production of viable CD8+ memory T cells. | lld:pubmed |
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| pubmed-article:10755614 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10755614 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10755614 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10755614 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10755614 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:10755614 | pubmed:author | pubmed-author:RaevuoriMM | lld:pubmed |
| pubmed-article:10755614 | pubmed:author | pubmed-author:FukudaMM | lld:pubmed |
| pubmed-article:10755614 | pubmed:author | pubmed-author:ChuiDD | lld:pubmed |
| pubmed-article:10755614 | pubmed:author | pubmed-author:SimmonsC JCJ | lld:pubmed |
| pubmed-article:10755614 | pubmed:author | pubmed-author:HiraokaNN | lld:pubmed |
| pubmed-article:10755614 | pubmed:author | pubmed-author:VarkiN MNM | lld:pubmed |
| pubmed-article:10755614 | pubmed:author | pubmed-author:PageD MDM | lld:pubmed |
| pubmed-article:10755614 | pubmed:author | pubmed-author:PriatelJ JJJ | lld:pubmed |
| pubmed-article:10755614 | pubmed:author | pubmed-author:RichardsonK... | lld:pubmed |
| pubmed-article:10755614 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10755614 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:10755614 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10755614 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10755614 | pubmed:pagination | 273-83 | lld:pubmed |
| pubmed-article:10755614 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10755614 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10755614 | pubmed:articleTitle | The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis. | lld:pubmed |
| pubmed-article:10755614 | pubmed:affiliation | Howard Hughes Medical Institute, the Glycobiology Research and Training Center, and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093, USA. | lld:pubmed |
| pubmed-article:10755614 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10755614 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10755614 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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