| pubmed-article:10747194 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10747194 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:10747194 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10747194 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:10747194 | lifeskim:mentions | umls-concept:C0222660 | lld:lifeskim |
| pubmed-article:10747194 | lifeskim:mentions | umls-concept:C1511498 | lld:lifeskim |
| pubmed-article:10747194 | lifeskim:mentions | umls-concept:C0231530 | lld:lifeskim |
| pubmed-article:10747194 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:10747194 | lifeskim:mentions | umls-concept:C0441722 | lld:lifeskim |
| pubmed-article:10747194 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:10747194 | lifeskim:mentions | umls-concept:C2926735 | lld:lifeskim |
| pubmed-article:10747194 | pubmed:dateCreated | 2000-6-2 | lld:pubmed |
| pubmed-article:10747194 | pubmed:abstractText | 1. We examined the mechanisms for rate-dependent changes in twitch force duration by simultaneously measuring force and [Ca2+]i in rat cardiac trabeculae. 2. Peak force decreased when the rate of stimulation was increased from 0.2 to 0.5 Hz, whilst it increased from 1 to 2 Hz. Over the same range of frequencies, peak [Ca2+]i transients increased monotonically, whilst both force and [Ca2+]i transient duration were abbreviated. 3. Changes in peak force or peak [Ca2+]i transients were not responsible for the changes in force or [Ca2+]i transient duration. 4. The changes in twitch force and [Ca2+]i transient duration were completed roughly within one beat following an abrupt change in the rate of stimulation. 5. Rate-dependent changes resembled those observed with isoproterenol (isoprenaline) application. However, kinase inhibitors (i.e. K252-a, H-89, KN-62 and KN-93) had no effect on the rate-dependent changes of twitch force and [Ca2+]i transient kinetics, suggesting that protein kinase A (PKA), protein kinase PKG) and Ca2+-calmodulin-dependent protein kinase II (CaM/kinase II) were not responsible for these kinetic changes. 6. Despite the changes in twitch force and [Ca2+]i transient kinetics, the rate-limiting step for the rate-dependent force relaxation still resides at the level of the contractile proteins. 7. Our results suggest that rate-dependent changes in force and [Ca2+]i transients do not depend on PKA or CaM/kinase II activity but might result from intrinsic features of the contractile and/or Ca2+-handling proteins. | lld:pubmed |
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| pubmed-article:10747194 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10747194 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10747194 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10747194 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10747194 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10747194 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:10747194 | pubmed:author | pubmed-author:MyersRR | lld:pubmed |
| pubmed-article:10747194 | pubmed:author | pubmed-author:BackxP HPH | lld:pubmed |
| pubmed-article:10747194 | pubmed:author | pubmed-author:BanijamaliH... | lld:pubmed |
| pubmed-article:10747194 | pubmed:author | pubmed-author:KaprielianRR | lld:pubmed |
| pubmed-article:10747194 | pubmed:author | pubmed-author:KassiriZZ | lld:pubmed |
| pubmed-article:10747194 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10747194 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10747194 | pubmed:volume | 524 Pt 1 | lld:pubmed |
| pubmed-article:10747194 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10747194 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10747194 | pubmed:pagination | 221-31 | lld:pubmed |
| pubmed-article:10747194 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:10747194 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10747194 | pubmed:articleTitle | Rate-dependent changes of twitch force duration in rat cardiac trabeculae: a property of the contractile system. | lld:pubmed |
| pubmed-article:10747194 | pubmed:affiliation | Departments of Physiology and Medicine and University Health Network (General Division), University of Toronto, CCRW 3-802, Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:10747194 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10747194 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:10747194 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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