Linked Life Data

10738244

Source:http://linkedlifedata.com/resource/pubmed/id/10738244

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10738244rdf:typepubmed:Citationlld:pubmed
pubmed-article:10738244lifeskim:mentionsumls-concept:C0699790lld:lifeskim
pubmed-article:10738244lifeskim:mentionsumls-concept:C0162638lld:lifeskim
pubmed-article:10738244lifeskim:mentionsumls-concept:C1882628lld:lifeskim
pubmed-article:10738244lifeskim:mentionsumls-concept:C1518174lld:lifeskim
pubmed-article:10738244lifeskim:mentionsumls-concept:C0059285lld:lifeskim
pubmed-article:10738244lifeskim:mentionsumls-concept:C0332206lld:lifeskim
pubmed-article:10738244pubmed:issue2lld:pubmed
pubmed-article:10738244pubmed:dateCreated2000-4-20lld:pubmed
pubmed-article:10738244pubmed:abstractTextImbalanced proliferation and apoptosis is important in tumor progression. Endothelin (ET)-1, a 21-amino-acid peptide with vasoconstricting and mitogenic activities, has been shown to be involved in the regulation of apoptosis. Progressive and regressive rat colon (PROb and REGb cells) carcinoma cell lines express the components of the ET-1 system (preproET-1, ET-converting enzyme and ET-receptors) and secrete ET-1. These cells also express the Fas(APO-1, CD95)/FasL system, but are resistant to FasL-induced apoptosis. We thus addressed the role of ET-1 in FasL-dependent cell death. Bosentan, a mixed ET(A)/ET(B) receptor antagonist, potentiated FasL-induced apoptosis in these cells. At low concentrations (10(-13) to 10(-10) M), ET-1 dose-dependently reversed bosentan-induced apoptosis. Bosentan sensitization to FasL-induced apoptosis was not mediated by increased expression of Fas receptor and was blocked by the caspase inhibitor zVAD-fmk. The specific inhibition of enzymes involved in ceramide production did not restore survival of cells exposed to FasL and bosentan. Our results suggest that ET-1 is a survival factor able to protect in vitro colon carcinoma cells against FasL-induced apoptosis.lld:pubmed
pubmed-article:10738244pubmed:languageenglld:pubmed
pubmed-article:10738244pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:citationSubsetIMlld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10738244pubmed:statusMEDLINElld:pubmed
pubmed-article:10738244pubmed:monthAprlld:pubmed
pubmed-article:10738244pubmed:issn0020-7136lld:pubmed
pubmed-article:10738244pubmed:authorpubmed-author:JeanninJ FJFlld:pubmed
pubmed-article:10738244pubmed:authorpubmed-author:Juillerat-Jea...lld:pubmed
pubmed-article:10738244pubmed:authorpubmed-author:ValdenaireOOlld:pubmed
pubmed-article:10738244pubmed:authorpubmed-author:EberlL PLPlld:pubmed
pubmed-article:10738244pubmed:authorpubmed-author:SaintgiorgioV...lld:pubmed
pubmed-article:10738244pubmed:copyrightInfoCopyright 2000 Wiley-Liss, Inc.lld:pubmed
pubmed-article:10738244pubmed:issnTypePrintlld:pubmed
pubmed-article:10738244pubmed:day15lld:pubmed
pubmed-article:10738244pubmed:volume86lld:pubmed
pubmed-article:10738244pubmed:ownerNLMlld:pubmed
pubmed-article:10738244pubmed:authorsCompleteYlld:pubmed
pubmed-article:10738244pubmed:pagination182-7lld:pubmed
pubmed-article:10738244pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:meshHeadingpubmed-meshheading:10738244...lld:pubmed
pubmed-article:10738244pubmed:year2000lld:pubmed
pubmed-article:10738244pubmed:articleTitleEndothelin receptor blockade potentiates FasL-induced apoptosis in rat colon carcinoma cells.lld:pubmed
pubmed-article:10738244pubmed:affiliationInstitute of Pathology, University of Lausanne, Lausanne, Switzerland.lld:pubmed
pubmed-article:10738244pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10738244pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10738244lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10738244lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10738244lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10738244lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10738244lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10738244lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10738244lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10738244lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10738244lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10738244lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10738244lld:pubmed