| pubmed-article:10737774 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10737774 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:10737774 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10737774 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:10737774 | lifeskim:mentions | umls-concept:C0162759 | lld:lifeskim |
| pubmed-article:10737774 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:10737774 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:10737774 | lifeskim:mentions | umls-concept:C0170210 | lld:lifeskim |
| pubmed-article:10737774 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:10737774 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:10737774 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:10737774 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:10737774 | pubmed:dateCreated | 2000-5-17 | lld:pubmed |
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| pubmed-article:10737774 | pubmed:abstractText | Few molecular events important to platelet biogenesis have been identified. Mice homozygous for the spontaneous, recessive mutation gunmetal (gm) have prolonged bleeding, thrombocytopenia, and reduced platelet alpha- and delta-granule contents. Here we show by positional cloning that gm results from a G-->A substitution mutation in a splice acceptor site within the alpha-subunit of Rab geranylgeranyl transferase (Rabggta), an enzyme that attaches geranylgeranyl groups to Rab proteins. Most Rabggta mRNAs from gm tissues skipped exon 1 and lacked a start codon. Rabggta protein and Rab geranylgeranyl transferase (GGTase) activity were reduced 4-fold in gm platelets. Geranylgeranylation and membrane association of Rab27, a Rab GGTase substrate, were significantly decreased in gm platelets. These findings indicate that geranylgeranylation of Rab GTPases is critical for hemostasis. Rab GGTase inhibition may represent a new treatment for thrombocytosis and clotting disorders. | lld:pubmed |
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| pubmed-article:10737774 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10737774 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10737774 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10737774 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10737774 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10737774 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10737774 | pubmed:author | pubmed-author:SwankR TRT | lld:pubmed |
| pubmed-article:10737774 | pubmed:author | pubmed-author:DetterJ CJC | lld:pubmed |
| pubmed-article:10737774 | pubmed:author | pubmed-author:NovakE KEK | lld:pubmed |
| pubmed-article:10737774 | pubmed:author | pubmed-author:WallaceM RMR | lld:pubmed |
| pubmed-article:10737774 | pubmed:author | pubmed-author:LUCC | lld:pubmed |
| pubmed-article:10737774 | pubmed:author | pubmed-author:ZhangQQ | lld:pubmed |
| pubmed-article:10737774 | pubmed:author | pubmed-author:MulesE HEH | lld:pubmed |
| pubmed-article:10737774 | pubmed:author | pubmed-author:SeabraM CMC | lld:pubmed |
| pubmed-article:10737774 | pubmed:author | pubmed-author:KingsmoreS... | lld:pubmed |
| pubmed-article:10737774 | pubmed:author | pubmed-author:MishraV SVS | lld:pubmed |
| pubmed-article:10737774 | pubmed:author | pubmed-author:McMurtrieE... | lld:pubmed |
| pubmed-article:10737774 | pubmed:author | pubmed-author:TchernevV TVT | lld:pubmed |
| pubmed-article:10737774 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10737774 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:10737774 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:10737774 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10737774 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10737774 | pubmed:pagination | 4144-9 | lld:pubmed |
| pubmed-article:10737774 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10737774 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10737774 | pubmed:articleTitle | Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis. | lld:pubmed |
| pubmed-article:10737774 | pubmed:affiliation | Departments of Medicine, Molecular Genetics and Microbiology, Pathology and Laboratory Medicine, and Pediatrics, and Center for Mammalian Genetics, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA. | lld:pubmed |
| pubmed-article:10737774 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10737774 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10737774 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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