| pubmed-article:10736207 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10736207 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:10736207 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:10736207 | lifeskim:mentions | umls-concept:C0028944 | lld:lifeskim |
| pubmed-article:10736207 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:10736207 | lifeskim:mentions | umls-concept:C0380603 | lld:lifeskim |
| pubmed-article:10736207 | lifeskim:mentions | umls-concept:C0032200 | lld:lifeskim |
| pubmed-article:10736207 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:10736207 | lifeskim:mentions | umls-concept:C2755994 | lld:lifeskim |
| pubmed-article:10736207 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:10736207 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10736207 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:10736207 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:10736207 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10736207 | pubmed:dateCreated | 2000-6-19 | lld:pubmed |
| pubmed-article:10736207 | pubmed:abstractText | In this paper we address the linking of platelet-derived growth factor (PDGF) and basic fibroblast growth factor (FGF-2) to intracellular signaling molecules in oligodendrocyte progenitors. It is demonstrated that both growth factors activate downstream targets similar to those shown for protein kinase C (PKC) activation. Yet, neither the arrest of terminal oligodendrocyte differentiation nor the proliferation induced by PDGF or FGF-2 can be antagonized by inhibition of PKC. Rather, p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, and pp70 S6 kinase were found to be necessary for the mitogenic activity of PDGF and FGF-2. Paradoxically, these kinases were also necessary for the onset of oligodendrocyte differentiation in control cells. In addition, cAMP-dependent kinase A (PKA) activation inhibited the mitogenic response of oligodendrocyte progenitors to FGF-2. Taken together, the molecular mechanism that controls oligodendrocyte lineage progression is operated by at least two signal pathways, which interfere either with proliferation and/or differentiation of oligodendrocyte progenitors. | lld:pubmed |
| pubmed-article:10736207 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10736207 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10736207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10736207 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10736207 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10736207 | pubmed:issn | 1044-7431 | lld:pubmed |
| pubmed-article:10736207 | pubmed:author | pubmed-author:de VriesHH | lld:pubmed |
| pubmed-article:10736207 | pubmed:author | pubmed-author:MetzBB | lld:pubmed |
| pubmed-article:10736207 | pubmed:author | pubmed-author:HoekstraDD | lld:pubmed |
| pubmed-article:10736207 | pubmed:author | pubmed-author:BansalRR | lld:pubmed |
| pubmed-article:10736207 | pubmed:author | pubmed-author:Bal?kJJ | lld:pubmed |
| pubmed-article:10736207 | pubmed:copyrightInfo | Copyright 2000 Academic Press. | lld:pubmed |
| pubmed-article:10736207 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10736207 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:10736207 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10736207 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10736207 | pubmed:pagination | 314-29 | lld:pubmed |
| pubmed-article:10736207 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10736207 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10736207 | pubmed:articleTitle | PDGF and FGF-2 signaling in oligodendrocyte progenitor cells: regulation of proliferation and differentiation by multiple intracellular signaling pathways. | lld:pubmed |
| pubmed-article:10736207 | pubmed:affiliation | Department of Physiological Chemistry, Faculty of Medical Sciences, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands. | lld:pubmed |
| pubmed-article:10736207 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10736207 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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