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pubmed-article:10734022pubmed:abstractTextThe effects of 6-mercaptopurine (6-MP) are mediated via its intracellular conversion to 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) nucleotide metabolites, the latter genetically controlled by thiopurine methyltransferase (TPMT). We sought to determine optimal therapeutic 6-MP metabolite levels and their correlation with medication-induced toxicity and TPMT genotype.lld:pubmed
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pubmed-article:10734022pubmed:articleTitlePharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease.lld:pubmed
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