| pubmed-article:10722740 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10722740 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10722740 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:10722740 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:10722740 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:10722740 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10722740 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:10722740 | lifeskim:mentions | umls-concept:C0002716 | lld:lifeskim |
| pubmed-article:10722740 | lifeskim:mentions | umls-concept:C0013126 | lld:lifeskim |
| pubmed-article:10722740 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:10722740 | lifeskim:mentions | umls-concept:C1622642 | lld:lifeskim |
| pubmed-article:10722740 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:10722740 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10722740 | pubmed:dateCreated | 2000-4-27 | lld:pubmed |
| pubmed-article:10722740 | pubmed:abstractText | APP-BP1 binds to the amyloid precursor protein (APP) carboxyl-terminal domain. Recent work suggests that APP-BP1 participates in a novel ubiquitinylation-related pathway involving the ubiquitin-like molecule NEDD8. We show here that, in vivo in mammalian cells, APP-BP1 interacts with hUba3, its presumptive partner in the NEDD8 activation pathway, and that the APP-BP1 binding site for hUba3 is within amino acids 443-479. We also provide evidence that the human APP-BP1 molecule can rescue the ts41 mutation in Chinese hamster cells. This mutation previously has been shown to lead to successive S phases of the cell cycle without intervening G(2), M, and G(1), suggesting that the product of this gene negatively regulates entry into the S phase and positively regulates entry into mitosis. We show that expression of APP-BP1 in ts41 cells drives the cell cycle through the S-M checkpoint and that this function requires both hUba3 and hUbc12. Overexpression of APP-BP1 in primary neurons causes apoptosis via the same pathway. A specific caspase-6 inhibitor blocks this apoptosis. These findings are discussed in the context of abnormalities in the cell cycle that have been observed in Alzheimer's disease. | lld:pubmed |
| pubmed-article:10722740 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722740 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10722740 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722740 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10722740 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10722740 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10722740 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10722740 | pubmed:author | pubmed-author:ChenYY | lld:pubmed |
| pubmed-article:10722740 | pubmed:author | pubmed-author:NeveR LRL | lld:pubmed |
| pubmed-article:10722740 | pubmed:author | pubmed-author:HirschbergJJ | lld:pubmed |
| pubmed-article:10722740 | pubmed:author | pubmed-author:McPhieD LDL | lld:pubmed |
| pubmed-article:10722740 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10722740 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:10722740 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:10722740 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10722740 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10722740 | pubmed:pagination | 8929-35 | lld:pubmed |
| pubmed-article:10722740 | pubmed:dateRevised | 2008-8-21 | lld:pubmed |
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| pubmed-article:10722740 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10722740 | pubmed:articleTitle | The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. | lld:pubmed |
| pubmed-article:10722740 | pubmed:affiliation | Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA. | lld:pubmed |
| pubmed-article:10722740 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10722740 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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