| pubmed-article:10722430 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10722430 | lifeskim:mentions | umls-concept:C0014507 | lld:lifeskim |
| pubmed-article:10722430 | lifeskim:mentions | umls-concept:C0001699 | lld:lifeskim |
| pubmed-article:10722430 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:10722430 | lifeskim:mentions | umls-concept:C0004610 | lld:lifeskim |
| pubmed-article:10722430 | lifeskim:mentions | umls-concept:C0008809 | lld:lifeskim |
| pubmed-article:10722430 | lifeskim:mentions | umls-concept:C0597979 | lld:lifeskim |
| pubmed-article:10722430 | lifeskim:mentions | umls-concept:C0370215 | lld:lifeskim |
| pubmed-article:10722430 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:10722430 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:10722430 | lifeskim:mentions | umls-concept:C0678227 | lld:lifeskim |
| pubmed-article:10722430 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10722430 | pubmed:dateCreated | 2000-5-19 | lld:pubmed |
| pubmed-article:10722430 | pubmed:abstractText | A prospective study of Klebsiella pneumoniae bacteremia was performed in 12 hospitals in 7 countries. Of 452 episodes of bacteremia, 25 (5.5%) were caused by K. pneumoniae that was resistant in vitro to ciprofloxacin. Extended-spectrum beta-lactamase (ESBL) production was detected in 15 (60%) of 25 ciprofloxacin-resistant isolates, compared with 68 (16%) of 427 ciprofloxacin-susceptible strains (P=.0001). Multivariate analysis revealed that risk factors for ciprofloxacin resistance in K. pneumoniae included prior receipt of a quinolone (P=.0065) and an ESBL-producing strain (P=.012). In all, 18% of ESBL-producing isolates were also ciprofloxacin-resistant. Pulsed-field gel electrophoresis showed that 11 of the 15 ciprofloxacin-resistant ESBL-producing strains belonged to just 4 genotypes, suggesting that patient-to-patient transmission of such strains occurred. The close relationship between ESBL production and ciprofloxacin resistance is particularly worrisome because the first reported instance of plasmid-mediated ciprofloxacin resistance has been in an isolate of K. pneumoniae also possessing an ESBL. | lld:pubmed |
| pubmed-article:10722430 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10722430 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722430 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10722430 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10722430 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10722430 | pubmed:issn | 1058-4838 | lld:pubmed |
| pubmed-article:10722430 | pubmed:author | pubmed-author:McCormackJ... | lld:pubmed |
| pubmed-article:10722430 | pubmed:author | pubmed-author:TrenholmeG... | lld:pubmed |
| pubmed-article:10722430 | pubmed:author | pubmed-author:KoW CWC | lld:pubmed |
| pubmed-article:10722430 | pubmed:author | pubmed-author:YuV LVL | lld:pubmed |
| pubmed-article:10722430 | pubmed:author | pubmed-author:CasellasJ MJM | lld:pubmed |
| pubmed-article:10722430 | pubmed:author | pubmed-author:GoossensHH | lld:pubmed |
| pubmed-article:10722430 | pubmed:author | pubmed-author:KlugmanK PKP | lld:pubmed |
| pubmed-article:10722430 | pubmed:author | pubmed-author:MohapatraSS | lld:pubmed |
| pubmed-article:10722430 | pubmed:author | pubmed-author:PatersonD LDL | lld:pubmed |
| pubmed-article:10722430 | pubmed:author | pubmed-author:MulazimogluLL | lld:pubmed |
| pubmed-article:10722430 | pubmed:author | pubmed-author:Von... | lld:pubmed |
| pubmed-article:10722430 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10722430 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:10722430 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10722430 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10722430 | pubmed:pagination | 473-8 | lld:pubmed |
| pubmed-article:10722430 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:10722430 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10722430 | pubmed:articleTitle | Epidemiology of ciprofloxacin resistance and its relationship to extended-spectrum beta-lactamase production in Klebsiella pneumoniae isolates causing bacteremia. | lld:pubmed |
| pubmed-article:10722430 | pubmed:affiliation | Infectious Disease Section, Veterans Affairs Medical Center, Pittsburgh, PA 15240, USA. | lld:pubmed |
| pubmed-article:10722430 | pubmed:publicationType | Journal Article | lld:pubmed |
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