| pubmed-article:10717483 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10717483 | lifeskim:mentions | umls-concept:C0035804 | lld:lifeskim |
| pubmed-article:10717483 | lifeskim:mentions | umls-concept:C0205341 | lld:lifeskim |
| pubmed-article:10717483 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:10717483 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:10717483 | lifeskim:mentions | umls-concept:C0086908 | lld:lifeskim |
| pubmed-article:10717483 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10717483 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:10717483 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10717483 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10717483 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:10717483 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10717483 | pubmed:dateCreated | 2000-5-2 | lld:pubmed |
| pubmed-article:10717483 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10717483 | pubmed:abstractText | Pax-6 encodes a transcription factor that is important in the development of eye and CNS. Identification of Pax-6 target genes is crucial for understanding the gene regulatory network in these developmental processes. Using an in-vitro approach of cyclic amplification of the protein binding sequences (CAPBS), we isolated a PAX6 binding sequence from a human single-copy (sc) DNA library. Characterization of this PAX6 binding sequence revealed a 15bp region (hGCalpha1BLs5) that is sufficient for PAX6 specific binding. From a homology search in the GenBank, we found that an hGCalpha1BLs5-like Pax-6 binding site exists in 21 genes (16 from rodent), 15 of which were shown to be able to bind Pax-6 in vitro. Interestingly, some of these sites occur in B1 repetitive elements. Although hGCalpha1BLs5 is highly similar to a region in B1 repetitive elements, PAX6 does not bind to the consensus sequence in B1. However, a single-step mutation in some B1 elements can lead to a gain of function for PAX6 binding. This experimental evidence and phylogenetic analysis raise an interesting speculation for the coevolution between PAX6 regulation and repeat elements. Since a (Pax-6-binding) null B1 element can be re-activated by even a single-step mutation, it has the potential to recruit gene targets for Pax-6 if it is inserted into the regulatory region, and therefore may play a role for evolutionary modification of Pax-6 regulation. | lld:pubmed |
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| pubmed-article:10717483 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10717483 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10717483 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10717483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10717483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10717483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10717483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10717483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10717483 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10717483 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10717483 | pubmed:issn | 0378-1119 | lld:pubmed |
| pubmed-article:10717483 | pubmed:author | pubmed-author:SaundersG FGF | lld:pubmed |
| pubmed-article:10717483 | pubmed:author | pubmed-author:LUCC | lld:pubmed |
| pubmed-article:10717483 | pubmed:author | pubmed-author:ZhouYY | lld:pubmed |
| pubmed-article:10717483 | pubmed:author | pubmed-author:LEEO KOK | lld:pubmed |
| pubmed-article:10717483 | pubmed:author | pubmed-author:ZhengJ BJB | lld:pubmed |
| pubmed-article:10717483 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10717483 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:10717483 | pubmed:volume | 245 | lld:pubmed |
| pubmed-article:10717483 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10717483 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10717483 | pubmed:pagination | 319-28 | lld:pubmed |
| pubmed-article:10717483 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10717483 | pubmed:meshHeading | pubmed-meshheading:10717483... | lld:pubmed |
| pubmed-article:10717483 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10717483 | pubmed:articleTitle | A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements? | lld:pubmed |
| pubmed-article:10717483 | pubmed:affiliation | Department of Biochemistry, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. sa51001@odin.mdacc.tmc.edu | lld:pubmed |
| pubmed-article:10717483 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10717483 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10717483 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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