| pubmed-article:10713716 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10713716 | lifeskim:mentions | umls-concept:C1704928 | lld:lifeskim |
| pubmed-article:10713716 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:10713716 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10713716 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:10713716 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10713716 | pubmed:dateCreated | 2000-6-12 | lld:pubmed |
| pubmed-article:10713716 | pubmed:abstractText | The c-Abl tyrosine kinase and its transforming variants have been implicated in tumorigenesis and in many important cellular processes. c-Abl is localized in the nucleus and the cytoplasm, where it plays distinct roles. The effects of c-Abl are mediated by multiple protein-protein and protein-DNA interactions and its tyrosine kinase domain. At the biochemical level, the mechanism of c-Abl kinase activation and the identification of its target proteins and cellular machineries have in part been solved. However, the phenotypic outcomes of these molecular events remained in large elusive. c-Abl has been shown to regulate the cell cycle and to induce under certain conditions cell growth arrest and apoptosis. In this respect the interaction of c-Abl with p53 and p73 has attracted particular attention. Recent findings have implicated c-Abl in an ionizing irradiation signaling pathway that elicits apoptosis. In this pathway p73 is an important immediate downstream effector. Here I review the current knowledge about these nuclear processes in which c-Abl is engaged and discuss some of their possible implications on cell physiology. Cell Death and Differentiation (2000) 7, 10 - 16. | lld:pubmed |
| pubmed-article:10713716 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10713716 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10713716 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10713716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10713716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10713716 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10713716 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10713716 | pubmed:issn | 1350-9047 | lld:pubmed |
| pubmed-article:10713716 | pubmed:author | pubmed-author:ShaulYY | lld:pubmed |
| pubmed-article:10713716 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10713716 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:10713716 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10713716 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10713716 | pubmed:pagination | 10-6 | lld:pubmed |
| pubmed-article:10713716 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10713716 | pubmed:meshHeading | pubmed-meshheading:10713716... | lld:pubmed |
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| pubmed-article:10713716 | pubmed:meshHeading | pubmed-meshheading:10713716... | lld:pubmed |
| pubmed-article:10713716 | pubmed:meshHeading | pubmed-meshheading:10713716... | lld:pubmed |
| pubmed-article:10713716 | pubmed:meshHeading | pubmed-meshheading:10713716... | lld:pubmed |
| pubmed-article:10713716 | pubmed:meshHeading | pubmed-meshheading:10713716... | lld:pubmed |
| pubmed-article:10713716 | pubmed:meshHeading | pubmed-meshheading:10713716... | lld:pubmed |
| pubmed-article:10713716 | pubmed:meshHeading | pubmed-meshheading:10713716... | lld:pubmed |
| pubmed-article:10713716 | pubmed:meshHeading | pubmed-meshheading:10713716... | lld:pubmed |
| pubmed-article:10713716 | pubmed:meshHeading | pubmed-meshheading:10713716... | lld:pubmed |
| pubmed-article:10713716 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10713716 | pubmed:articleTitle | c-Abl: activation and nuclear targets. | lld:pubmed |
| pubmed-article:10713716 | pubmed:affiliation | Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. yosef.shaul@weizmann.ac.il | lld:pubmed |
| pubmed-article:10713716 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10713716 | pubmed:publicationType | Review | lld:pubmed |
| entrez-gene:7157 | entrezgene:pubmed | pubmed-article:10713716 | lld:entrezgene |
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