| pubmed-article:10712203 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10712203 | lifeskim:mentions | umls-concept:C0254123 | lld:lifeskim |
| pubmed-article:10712203 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:10712203 | lifeskim:mentions | umls-concept:C0162735 | lld:lifeskim |
| pubmed-article:10712203 | lifeskim:mentions | umls-concept:C1704970 | lld:lifeskim |
| pubmed-article:10712203 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:10712203 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10712203 | pubmed:dateCreated | 2000-4-20 | lld:pubmed |
| pubmed-article:10712203 | pubmed:abstractText | Despite intense study of the neurofibromatosis type 2 (NF2) tumor-suppressor protein merlin, the biological properties and tumor-suppressor functions of merlin are still largely unknown. In this study, we examined the molecular activities of NF2-causing mutant merlin proteins in transfected mammalian cells, to elucidate the merlin properties that are critical for tumor-suppressor function. Most important, we found that 80% of the merlin mutants studied significantly altered cell adhesion, causing cells to detach from the substratum. This finding implies a function for merlin in regulating cell-matrix attachment, and changes in cell adhesion caused by mutant protein expression may be an initial step in the pathogenesis of NF2. In addition, five different mutations in merlin caused a significant increase in detergent solubility of merlin compared to wild type, indicating a decreased ability to interact with the cytoskeleton. Although not correlated to the cell-adhesion phenotype, four missense mutations decreased the binding of merlin to the ERM-interacting protein EBP-50, implicating this interaction in merlin inhibition of cell growth. Last, we found that some NF2 point mutations in merlin most closely resembled gain-of-function alleles in their cellular phenotype, which suggests that mutant NF2 alleles may not always act in a loss-of-function manner, as had been assumed, but may include a spectrum of allelic types with different phenotypic effects on the function of the protein. In aggregate, these cellular phenotypes provide a useful assay for identifying the functional domains and molecular partners necessary for merlin tumor-suppressor activity. | lld:pubmed |
| pubmed-article:10712203 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10712203 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10712203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10712203 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10712203 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10712203 | pubmed:issn | 0002-9297 | lld:pubmed |
| pubmed-article:10712203 | pubmed:author | pubmed-author:CoxD RDR | lld:pubmed |
| pubmed-article:10712203 | pubmed:author | pubmed-author:StokowskiR... | lld:pubmed |
| pubmed-article:10712203 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10712203 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:10712203 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10712203 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10712203 | pubmed:pagination | 873-91 | lld:pubmed |
| pubmed-article:10712203 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10712203 | pubmed:meshHeading | pubmed-meshheading:10712203... | lld:pubmed |
| pubmed-article:10712203 | pubmed:meshHeading | pubmed-meshheading:10712203... | lld:pubmed |
| pubmed-article:10712203 | pubmed:meshHeading | pubmed-meshheading:10712203... | lld:pubmed |
| pubmed-article:10712203 | pubmed:meshHeading | pubmed-meshheading:10712203... | lld:pubmed |
| pubmed-article:10712203 | pubmed:meshHeading | pubmed-meshheading:10712203... | lld:pubmed |
| pubmed-article:10712203 | pubmed:meshHeading | pubmed-meshheading:10712203... | lld:pubmed |
| pubmed-article:10712203 | pubmed:meshHeading | pubmed-meshheading:10712203... | lld:pubmed |
