| pubmed-article:10711349 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10711349 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10711349 | lifeskim:mentions | umls-concept:C0041632 | lld:lifeskim |
| pubmed-article:10711349 | lifeskim:mentions | umls-concept:C0949860 | lld:lifeskim |
| pubmed-article:10711349 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10711349 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:10711349 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10711349 | pubmed:dateCreated | 2000-4-12 | lld:pubmed |
| pubmed-article:10711349 | pubmed:abstractText | 1. Cumulative concentration-effect curves for the selective prostanoid TP receptor agonist U46619 and six isoprostanes were constructed in the human isolated umbilical artery. 2. All compounds except 8-iso-PGF3 alpha produced concentration-dependent contractions. The contractile response to the isoprostanes increased with each cumulative addition up to a point, after which subsequent addition reduced the contraction below the previous level. This 'downturn' in the concentration-effect curve did not occur with U46619. 3. The potencies of the compounds tested were as follows (pEC50 +/- s.e.mean): U46619, 6.7 +/- 0.2; 8-iso-PGE2, 6.5 +/- 0.1; 8-iso-PGF2 alpha, 5.8 +/- 0.2; 8-iso-PGE1, 5.4 +/- 0.1; 8-iso-PGF1 alpha, 5.0 +/- 0.1; 8-iso-PGF2 beta > 4.8; 8-iso-PGF3 alpha >> 4.8 (n = 4-17). Neither 8-iso-PGF2 beta nor 8-iso-PGF3 alpha at 44 microM had a significant effect on cumulative concentration-effect curves to U46619. 4. The selective TP receptor antagonist GR32191 (0.1 microM) caused rightward shifts in the concentration-effect curves to all the active compounds. pA2 values for GR32191 against U46619, 8-iso-PGE2, 8-iso-PGF2 alpha, 8-iso-PGE1 were 7.6 +/- 0.2, 9 +/- 1, 8.2 +/- 0.3 and 7.7 +/- 0.3, respectively (n = 4). 5. Neither N omega-nitro-L-arginine methyl ester (100 microM) nor the selective DP receptor antagonist BW A868C (50 nM) affected the complex concentration-effect curve to 8-iso-PGE2 (n = 3). 6. Stable contractions to U46619 (1-3 microM) were unaffected by anandamide at concentrations up to 60 microM. | lld:pubmed |
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| pubmed-article:10711349 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10711349 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10711349 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10711349 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10711349 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10711349 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:10711349 | pubmed:author | pubmed-author:CrankshawD... | lld:pubmed |
| pubmed-article:10711349 | pubmed:author | pubmed-author:OliveiraLL | lld:pubmed |
| pubmed-article:10711349 | pubmed:author | pubmed-author:StallwoodN... | lld:pubmed |
| pubmed-article:10711349 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10711349 | pubmed:volume | 129 | lld:pubmed |
| pubmed-article:10711349 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10711349 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10711349 | pubmed:pagination | 509-14 | lld:pubmed |
| pubmed-article:10711349 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10711349 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10711349 | pubmed:articleTitle | Effects of some isoprostanes on the human umbilical artery in vitro. | lld:pubmed |
| pubmed-article:10711349 | pubmed:affiliation | Honours Biology & Pharmacology Programme, McMaster University, Hamilton, Ontario, Canada. | lld:pubmed |
| pubmed-article:10711349 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10711349 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:10711349 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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