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pubmed-article:10709810pubmed:abstractTextThe ability to trigger functional magnetic resonance imaging (fMRI) acquisitions related to the occurrence of EEG-based physiologic transients has changed the field of fMRI into a more dynamically based technique. By knowing the temporal relationship between focal increases in neuronal firing rates and the provoked focal increase in blood flow, investigators are able to maximize the fMR-linked images that show where the activity originates. Our mastery of recording EEG inside the bore of a MR scanner has also allowed us to develop cognitive paradigms that record not only the fMR BOLD images, but also the evoked potentials (EPs). The EPs can subsequently be subjected to localization paradigms that can be compared to the localization seen on the BOLD images. These two techniques will most probably be complimentary. BOLD responses are dependent on a focal increase in metabolic demand while the EPs may or may not be related to energy demand increases. Additionally, recording EPs require that the source or sources of that potential come from an area that is able to generate far-field potentials. These potentials are related to the laminar organization of the neuronal population generating that potential. As best we know the BOLD response does not depend on any inherent laminar neuronal organization. Therefore, by merging these two recording methods, it is likely that we will gain a more detailed understanding of not only the areas involved in certain physiologic events, e.g. focal epilepsy or cognitive processing, but also on the sequencing of the activation of the various participating regions.lld:pubmed
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pubmed-article:10709810pubmed:dateRevised2005-11-16lld:pubmed
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pubmed-article:10709810pubmed:articleTitleEEG-Linked functional magnetic resonance imaging in epilepsy and cognitive neurophysiology.lld:pubmed
pubmed-article:10709810pubmed:affiliationNeurology Department, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215, USA.lld:pubmed
pubmed-article:10709810pubmed:publicationTypeJournal Articlelld:pubmed
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