| pubmed-article:10707113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10707113 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:10707113 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10707113 | lifeskim:mentions | umls-concept:C0011185 | lld:lifeskim |
| pubmed-article:10707113 | lifeskim:mentions | umls-concept:C0032950 | lld:lifeskim |
| pubmed-article:10707113 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10707113 | lifeskim:mentions | umls-concept:C0201734 | lld:lifeskim |
| pubmed-article:10707113 | lifeskim:mentions | umls-concept:C1709518 | lld:lifeskim |
| pubmed-article:10707113 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10707113 | pubmed:dateCreated | 2000-3-23 | lld:pubmed |
| pubmed-article:10707113 | pubmed:abstractText | The effects of multiple-dosing with dehydroepiandrosterone sulfate (DHEA-SO4) on the pharmacokinetics and pharmacodynamics of prednisolone were examined. Prednisolone (25 mg/kg i.v.) was administered to male and female Sprague-Dawley rats (250-350 g) alone and following DHEA-SO4 (4 mg/kg i.v., every 8 h for 4 days). Male control rats cleared prednisolone faster [3.68 +/- 1.30 (males) vs 1.01 +/- 0.7 l/h/kg; p < 0.05] and had larger Vss (1.38 +/- 0.459 vs 0.394 +/- 0.500 l/kg; p < 0.05) than females both due largely to lesser plasma protein binding. Prednisolone clearance and Vss were not altered by DHEA-SO4 in males or females. The net effect of prednisolone on basophils and plasma corticosterone did not differ with gender. DHEA-SO4 had no effect on plasma corticosterone and did not alter prednisolone action. DHEA-SO4 inhibited basophil trafficking in males, but to a lesser extent than prednisolone, and antagonized the effect of prednisolone on basophil trafficking in both sexes. The steroid-sparing effect observed with DHEA clinically may not be due to an alteration of corticosteroid pharmacokinetics but partly to its ability to affect immune functions. | lld:pubmed |
| pubmed-article:10707113 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10707113 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10707113 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10707113 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10707113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10707113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10707113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10707113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10707113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10707113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10707113 | pubmed:issn | 0792-5077 | lld:pubmed |
| pubmed-article:10707113 | pubmed:author | pubmed-author:JuskoW JWJ | lld:pubmed |
| pubmed-article:10707113 | pubmed:author | pubmed-author:HonY YYY | lld:pubmed |
| pubmed-article:10707113 | pubmed:author | pubmed-author:Meno-TetangG... | lld:pubmed |
| pubmed-article:10707113 | pubmed:author | pubmed-author:Van WartSS | lld:pubmed |
| pubmed-article:10707113 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10707113 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:10707113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10707113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10707113 | pubmed:pagination | 51-70 | lld:pubmed |
| pubmed-article:10707113 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10707113 | pubmed:meshHeading | pubmed-meshheading:10707113... | lld:pubmed |
| pubmed-article:10707113 | pubmed:meshHeading | pubmed-meshheading:10707113... | lld:pubmed |
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| pubmed-article:10707113 | pubmed:meshHeading | pubmed-meshheading:10707113... | lld:pubmed |
| pubmed-article:10707113 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10707113 | pubmed:articleTitle | Pharmacokinetic and pharmacodynamic interactions between dehydroepiandrosterone and prednisolone in the rat. | lld:pubmed |
| pubmed-article:10707113 | pubmed:affiliation | Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo 14260, USA. | lld:pubmed |
| pubmed-article:10707113 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10707113 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
