| pubmed-article:10706290 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10706290 | lifeskim:mentions | umls-concept:C0003374 | lld:lifeskim |
| pubmed-article:10706290 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:10706290 | lifeskim:mentions | umls-concept:C0032150 | lld:lifeskim |
| pubmed-article:10706290 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:10706290 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:10706290 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:10706290 | pubmed:issue | 6772 | lld:pubmed |
| pubmed-article:10706290 | pubmed:dateCreated | 2000-3-21 | lld:pubmed |
| pubmed-article:10706290 | pubmed:abstractText | Throughout the latter half of this century, the development and spread of resistance to most front-line antimalarial compounds used in the prevention and treatment of the most severe form of human malaria has given cause for grave clinical concern. Polymorphisms in pfmdr1, the gene encoding the P-glycoprotein homologue 1 (Pgh1) protein of Plasmodium falciparum, have been linked to chloroquine resistance; Pgh1 has also been implicated in resistance to mefloquine and halofantrine. However, conclusive evidence of a direct causal association between pfmdr1 and resistance to these antimalarials has remained elusive, and a single genetic cross has suggested that Pgh1 is not involved in resistance to chloroquine and mefloquine. Here we provide direct proof that mutations in Pgh1 can confer resistance to mefloquine, quinine and halofantrine. The same mutations influence parasite resistance towards chloroquine in a strain-specific manner and the level of sensitivity to the structurally unrelated compound, artemisinin. This has important implications for the development and efficacy of future antimalarial agents. | lld:pubmed |
| pubmed-article:10706290 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10706290 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706290 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10706290 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10706290 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:10706290 | pubmed:author | pubmed-author:ReedM BMB | lld:pubmed |
| pubmed-article:10706290 | pubmed:author | pubmed-author:SalserS JSJ | lld:pubmed |
| pubmed-article:10706290 | pubmed:author | pubmed-author:CowmanA FAF | lld:pubmed |
| pubmed-article:10706290 | pubmed:author | pubmed-author:KirkKK | lld:pubmed |
| pubmed-article:10706290 | pubmed:author | pubmed-author:CaruanaS RSR | lld:pubmed |
| pubmed-article:10706290 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10706290 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:10706290 | pubmed:volume | 403 | lld:pubmed |
| pubmed-article:10706290 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10706290 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10706290 | pubmed:pagination | 906-9 | lld:pubmed |
| pubmed-article:10706290 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:meshHeading | pubmed-meshheading:10706290... | lld:pubmed |
| pubmed-article:10706290 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10706290 | pubmed:articleTitle | Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. | lld:pubmed |
| pubmed-article:10706290 | pubmed:affiliation | The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. | lld:pubmed |
| pubmed-article:10706290 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10706290 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10706290 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:813045 | entrezgene:pubmed | pubmed-article:10706290 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10706290 | lld:pubmed |
