| pubmed-article:10706097 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10706097 | lifeskim:mentions | umls-concept:C0042172 | lld:lifeskim |
| pubmed-article:10706097 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10706097 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10706097 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10706097 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:10706097 | lifeskim:mentions | umls-concept:C0752046 | lld:lifeskim |
| pubmed-article:10706097 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10706097 | pubmed:dateCreated | 2000-3-20 | lld:pubmed |
| pubmed-article:10706097 | pubmed:abstractText | E-cadherin plays a critical role in many aspects of cell adhesion, epithelial development, and the establishment and maintenance of epithelial polarity. The loss of the adhesive function of E-cadherin is a critical step in the promotion of epithelial cells to a more malignant phenotype. We identified a C/A single nucleotide polymorphism at -160 from the transcriptional start site of the E-cadherin gene promoter. Transient transfection experiments showed that the A allele of this polymorphism decreased the transcriptional efficiency by 68% compared with the C allele (P<0.001). Electrophoretic mobility shift and footprinting assays revealed that the C allele had a stronger transcriptional factor binding strength than the A allele. These results indicate that the -160 C/A polymorphism has a direct effect on E-cadherin gene transcriptional regulation. This allelic variation may be a potential genetic marker that can help identify those individuals at higher risk for invasive/metastatic diseases. | lld:pubmed |
| pubmed-article:10706097 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706097 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706097 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706097 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10706097 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706097 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10706097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10706097 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10706097 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10706097 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:10706097 | pubmed:author | pubmed-author:NakajimaKK | lld:pubmed |
| pubmed-article:10706097 | pubmed:author | pubmed-author:SasakiMM | lld:pubmed |
| pubmed-article:10706097 | pubmed:author | pubmed-author:HanJJ | lld:pubmed |
| pubmed-article:10706097 | pubmed:author | pubmed-author:KuL LLL | lld:pubmed |
| pubmed-article:10706097 | pubmed:author | pubmed-author:CarrollPP | lld:pubmed |
| pubmed-article:10706097 | pubmed:author | pubmed-author:DahiyaRR | lld:pubmed |
| pubmed-article:10706097 | pubmed:author | pubmed-author:ChunR FRF | lld:pubmed |
| pubmed-article:10706097 | pubmed:author | pubmed-author:NojimaDD | lld:pubmed |
| pubmed-article:10706097 | pubmed:author | pubmed-author:PerincheryGG | lld:pubmed |
| pubmed-article:10706097 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10706097 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10706097 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:10706097 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10706097 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10706097 | pubmed:pagination | 873-6 | lld:pubmed |
| pubmed-article:10706097 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10706097 | pubmed:meshHeading | pubmed-meshheading:10706097... | lld:pubmed |
| pubmed-article:10706097 | pubmed:meshHeading | pubmed-meshheading:10706097... | lld:pubmed |
| pubmed-article:10706097 | pubmed:meshHeading | pubmed-meshheading:10706097... | lld:pubmed |
| pubmed-article:10706097 | pubmed:meshHeading | pubmed-meshheading:10706097... | lld:pubmed |
| pubmed-article:10706097 | pubmed:meshHeading | pubmed-meshheading:10706097... | lld:pubmed |
| pubmed-article:10706097 | pubmed:meshHeading | pubmed-meshheading:10706097... | lld:pubmed |
| pubmed-article:10706097 | pubmed:meshHeading | pubmed-meshheading:10706097... | lld:pubmed |
| pubmed-article:10706097 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10706097 | pubmed:articleTitle | A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities. | lld:pubmed |
| pubmed-article:10706097 | pubmed:affiliation | Department of Urology, Veterans Affairs Medical Center, and University of California San Francisco, 94121, USA. | lld:pubmed |
| pubmed-article:10706097 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10706097 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10706097 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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