| pubmed-article:10704073 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10704073 | lifeskim:mentions | umls-concept:C0035891 | lld:lifeskim |
| pubmed-article:10704073 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10704073 | lifeskim:mentions | umls-concept:C0003240 | lld:lifeskim |
| pubmed-article:10704073 | lifeskim:mentions | umls-concept:C1327413 | lld:lifeskim |
| pubmed-article:10704073 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:10704073 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:10704073 | pubmed:issue | 4-5 | lld:pubmed |
| pubmed-article:10704073 | pubmed:dateCreated | 2000-3-21 | lld:pubmed |
| pubmed-article:10704073 | pubmed:abstractText | This study was designed to examine the influence of a macrolide antibiotic, roxithromycin (RXM), on the production of pro-inflammatory cytokines, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha. In the first experiments, we examined the effect of RXM on in vitro cytokine production from lipopolysaccharide (LPS)-stimulated human peripheral blood monocytes. The monocytes were cultured in the presence of various doses of the agent. After 24 h, the culture supernatants were obtained and assayed for IL-1beta and TNF-alpha contents by enzyme-linked immunosorbent assay. RXM suppressed the in vitro production of IL-1beta and TNF-alpha in response to LPS stimulation. This was dose dependent and first noted at a concentration of as little as 0.05 microg/ml, which is much lower than therapeutic blood levels. In the second part of the experiments, we examined the influence of RXM on the appearance of IL-1beta and TNF-alpha in mouse lung extract induced by LPS inhalation. RXM was administered orally into BALB/c mice at a single dose of 2.5 mg/kg once a day for 5-12 weeks. These mice were then instilled with LPS into the trachea and examined for the presence of cytokines in aqueous lung extracts. Pretreatment of mice with RXM for 5 weeks did not influence of the appearance of both IL-1beta and TNF-alpha in aqueous lung extracts. However, pretreatment for more than 7 weeks dramatically suppressed the cytokine appearance in the extracts. | lld:pubmed |
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| pubmed-article:10704073 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10704073 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10704073 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10704073 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10704073 | pubmed:issn | 0962-9351 | lld:pubmed |
| pubmed-article:10704073 | pubmed:author | pubmed-author:OhkiSS | lld:pubmed |
| pubmed-article:10704073 | pubmed:author | pubmed-author:MizutaniTT | lld:pubmed |
| pubmed-article:10704073 | pubmed:author | pubmed-author:KanaoMM | lld:pubmed |
| pubmed-article:10704073 | pubmed:author | pubmed-author:HisamitsuTT | lld:pubmed |
| pubmed-article:10704073 | pubmed:author | pubmed-author:AsanoKK | lld:pubmed |
| pubmed-article:10704073 | pubmed:author | pubmed-author:SuzakiHH | lld:pubmed |
| pubmed-article:10704073 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10704073 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:10704073 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10704073 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10704073 | pubmed:pagination | 199-204 | lld:pubmed |
| pubmed-article:10704073 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10704073 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10704073 | pubmed:articleTitle | Suppressive activity of a macrolide antibiotic, roxithromycin, on pro-inflammatory cytokine production in vitro and in vivo. | lld:pubmed |
| pubmed-article:10704073 | pubmed:affiliation | Department of Otolaryngology, School of Medicine, Showa University, Tokyo, Japan. | lld:pubmed |
| pubmed-article:10704073 | pubmed:publicationType | Journal Article | lld:pubmed |
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