| pubmed-article:10698352 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10698352 | lifeskim:mentions | umls-concept:C0014930 | lld:lifeskim |
| pubmed-article:10698352 | lifeskim:mentions | umls-concept:C0073096 | lld:lifeskim |
| pubmed-article:10698352 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:10698352 | lifeskim:mentions | umls-concept:C0720298 | lld:lifeskim |
| pubmed-article:10698352 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10698352 | pubmed:dateCreated | 2000-3-16 | lld:pubmed |
| pubmed-article:10698352 | pubmed:abstractText | Resveratrol, natural compound found in grapes and wine, has been reported to have a variety of health benefit properties. Based on the structural similarity to the synthetic estrogen diethylstilbestrol, we investigated estrogenic/antiestrogenic effects on human breast cancer cell lines, MCF-7 and MVLN, and scavenging properties using DPPH of both (E)- and (Z)-isomers. Both isomers increased the in vitro growth of MCF-7 cell lines at medium concentrations (10 and 25 microM) whereas the low concentrations (0.1 and 1 microM) had no effect and the high concentration (50 microM) decreased the cell growth and was cytotoxic. The 25 microM (E)-isomer alone was able to reduced the proliferation induced by the estradiol. Low concentrations of (E)- and (Z)-resveratrol (0.1 and 1 microM) and medium concentration 10 microM (Z)-resveratrol did not interfere with the estrogen receptor. In contrast, medium concentrations of (E)-resveratrol (10 and 25 microM) and (Z)-resveratrol (25 microM) functioned as superagonists of estradiol. Whatever the model used, MCF-7 or MVLN cell lines, (Z)-resveratrol was less effective than (E)-resveratrol. Extinction of DPPH and Fe(III) reduction experiments showed that both isomers of resveratrol could act as free radicals scavengers or pro-oxidant compounds. The properties of low concentrations of resveratrol raise the possibility that structure-function studies could lead to the development of more selective estrogen receptor agonists and antagonists, which could be useful as a therapeutic agent. | lld:pubmed |
| pubmed-article:10698352 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10698352 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10698352 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10698352 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10698352 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10698352 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10698352 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10698352 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10698352 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10698352 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10698352 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10698352 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10698352 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10698352 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10698352 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:10698352 | pubmed:author | pubmed-author:HabriouxGG | lld:pubmed |
| pubmed-article:10698352 | pubmed:author | pubmed-author:ChuliaA JAJ | lld:pubmed |
| pubmed-article:10698352 | pubmed:author | pubmed-author:BaslyJ PJP | lld:pubmed |
| pubmed-article:10698352 | pubmed:author | pubmed-author:Le BailJ CJC | lld:pubmed |
| pubmed-article:10698352 | pubmed:author | pubmed-author:Marre-Fournie... | lld:pubmed |
| pubmed-article:10698352 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10698352 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:10698352 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:10698352 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10698352 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10698352 | pubmed:pagination | 769-77 | lld:pubmed |
| pubmed-article:10698352 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
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| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
| pubmed-article:10698352 | pubmed:meshHeading | pubmed-meshheading:10698352... | lld:pubmed |
| pubmed-article:10698352 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10698352 | pubmed:articleTitle | Estrogenic/antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol. | lld:pubmed |
| pubmed-article:10698352 | pubmed:affiliation | UPRES EA 1085 Biomolécules et cibles cellulaires tumorales, UFR de Pharmacie, Limoges, France. basly@unilim.fr | lld:pubmed |
| pubmed-article:10698352 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10698352 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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