| pubmed-article:10692238 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10692238 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:10692238 | lifeskim:mentions | umls-concept:C2827749 | lld:lifeskim |
| pubmed-article:10692238 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10692238 | lifeskim:mentions | umls-concept:C1302234 | lld:lifeskim |
| pubmed-article:10692238 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10692238 | pubmed:dateCreated | 2000-4-7 | lld:pubmed |
| pubmed-article:10692238 | pubmed:abstractText | Neutralization of TNF or disruption of TNF-R1 leads to fatal Mycobacterium bovis BCG infection. Here we used TNF-LT-alpha-deficient mice to test whether a complete disruption of TNF and LT-alpha reduces further host resistance to BCG infection. The bacterial burden especially in the lungs of TNF-LT-alpha-deficient mice was significantly increased and the mice succumbed to infection between 8 and 10 weeks. In the absence of TNF-LT-alpha the granulomatous response was severely impaired and delayed. The cells in the granulomas of TNF-LT-alpha-deficient mice expressed low levels of MHC class II and ICAM-1. They contained a few T cells and F4/80-positive macrophages expressing little iNOS and acid phosphatase activity. By contrast, the lethal action of endotoxin was dramatically reduced in BCG-infected TNF-LT-alpha-deficient mice. In summary, in the absence of TNF-LT-alpha the recruitment and activation of mononuclear cells in response to BCG infection were significantly delayed and reduced resulting in immature granulomas allowing uncontrolled fatal infection. | lld:pubmed |
| pubmed-article:10692238 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10692238 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10692238 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10692238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10692238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10692238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10692238 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10692238 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10692238 | pubmed:issn | 1521-6616 | lld:pubmed |
| pubmed-article:10692238 | pubmed:author | pubmed-author:JacobsMM | lld:pubmed |
| pubmed-article:10692238 | pubmed:author | pubmed-author:BrownNN | lld:pubmed |
| pubmed-article:10692238 | pubmed:author | pubmed-author:RyffelBB | lld:pubmed |
| pubmed-article:10692238 | pubmed:author | pubmed-author:AllieNN | lld:pubmed |
| pubmed-article:10692238 | pubmed:copyrightInfo | Copyright 2000 Academic Press. | lld:pubmed |
| pubmed-article:10692238 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10692238 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:10692238 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10692238 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10692238 | pubmed:pagination | 192-9 | lld:pubmed |
| pubmed-article:10692238 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10692238 | pubmed:meshHeading | pubmed-meshheading:10692238... | lld:pubmed |
| pubmed-article:10692238 | pubmed:meshHeading | pubmed-meshheading:10692238... | lld:pubmed |
| pubmed-article:10692238 | pubmed:meshHeading | pubmed-meshheading:10692238... | lld:pubmed |
| pubmed-article:10692238 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10692238 | pubmed:articleTitle | Fatal Mycobacterium bovis BCG infection in TNF-LT-alpha-deficient mice. | lld:pubmed |
| pubmed-article:10692238 | pubmed:affiliation | Department of Immunology, University of Cape Town, Cape Town, South Africa. | lld:pubmed |
| pubmed-article:10692238 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10692238 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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