| pubmed-article:10692041 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10692041 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10692041 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:10692041 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10692041 | lifeskim:mentions | umls-concept:C2350466 | lld:lifeskim |
| pubmed-article:10692041 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10692041 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:10692041 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10692041 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:10692041 | lifeskim:mentions | umls-concept:C0534775 | lld:lifeskim |
| pubmed-article:10692041 | lifeskim:mentions | umls-concept:C1528871 | lld:lifeskim |
| pubmed-article:10692041 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10692041 | pubmed:dateCreated | 2000-3-15 | lld:pubmed |
| pubmed-article:10692041 | pubmed:abstractText | Human Valpha24 + NKT cells, a subpopulation of natural killer cell receptor (NKR-P1A) expressing T cells with an invariant T-cell receptor (TCR; Valpha24JalphaQ) are stimulated by the glycolipid, alpha-galactosylceramide (KRN7000), in a CD1d-dependent, TCR-mediated fashion. Little is known about Valpha24 + NKT-cell function. The murine counterpart, Valpha14 + NKT cells, appear to have an important role in controlling malignancy. There are no human data examining the role of Valpha24 + NKT cells in controlling human malignancy. We report that Valpha24 + NKT cells have perforin-mediated cytotoxicity against haemopoietic malignancies. Valpha24 TCR, CD1d and alpha-galactosylceramide may all play a role in cytotoxicity but are not absolute requirements. The greatest cytotoxicity was observed against the U937 tumour cell line (95 +/- 5% lysis). THP-1, Molt4, C1R cells and allogeneic mismatched dendritic cells were also sensitive to Valpha24 + NKT cytotoxicity but neither the NK target, K562, nor lymphokine-activated killer-sensitive Daudi cells, were sensitive. These results indicate a killing pattern distinct from conventional major histocompatibility complex-restricted T cells, NK cells and other cytotoxic lymphoid cells previously described. We conclude that human Valpha24 + NKT cells have cytotoxic anti-tumour activity against haemopoietic malignancies through effector mechanisms distinct from conventional T cells and NK cells and that their specific stimulator KRN7000 may have therapeutic potential. | lld:pubmed |
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| pubmed-article:10692041 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10692041 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10692041 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10692041 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10692041 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:10692041 | pubmed:author | pubmed-author:SuzukiKK | lld:pubmed |
| pubmed-article:10692041 | pubmed:author | pubmed-author:JujiTT | lld:pubmed |
| pubmed-article:10692041 | pubmed:author | pubmed-author:TadokoroKK | lld:pubmed |
| pubmed-article:10692041 | pubmed:author | pubmed-author:NicolAA | lld:pubmed |
| pubmed-article:10692041 | pubmed:author | pubmed-author:PorcelliSS | lld:pubmed |
| pubmed-article:10692041 | pubmed:author | pubmed-author:NiedaMM | lld:pubmed |
| pubmed-article:10692041 | pubmed:author | pubmed-author:DurrantSS | lld:pubmed |
| pubmed-article:10692041 | pubmed:author | pubmed-author:KoezukaYY | lld:pubmed |
| pubmed-article:10692041 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10692041 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:10692041 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10692041 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10692041 | pubmed:pagination | 229-34 | lld:pubmed |
| pubmed-article:10692041 | pubmed:dateRevised | 2010-2-25 | lld:pubmed |
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| pubmed-article:10692041 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10692041 | pubmed:articleTitle | Human invariant valpha24+ natural killer T cells activated by alpha-galactosylceramide (KRN7000) have cytotoxic anti-tumour activity through mechanisms distinct from T cells and natural killer cells. | lld:pubmed |
| pubmed-article:10692041 | pubmed:affiliation | Queensland Institute of Medical Research and Department of Medicine, University of Queensland, Royal Brisbane Hospital, Brisbane, Australia. | lld:pubmed |
| pubmed-article:10692041 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10692041 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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