| pubmed-article:10688915 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10688915 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:10688915 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:10688915 | lifeskim:mentions | umls-concept:C0694873 | lld:lifeskim |
| pubmed-article:10688915 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:10688915 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10688915 | pubmed:dateCreated | 2000-4-11 | lld:pubmed |
| pubmed-article:10688915 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10688915 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10688915 | pubmed:abstractText | The prototypic oncogene c-MYC encodes a transcription factor that can drive proliferation by promoting cell-cycle reentry. However, the mechanisms through which c-MYC achieves these effects have been unclear. Using serial analysis of gene expression, we have identified the cyclin-dependent kinase 4 (CDK4) gene as a transcriptional target of c-MYC. c-MYC induced a rapid increase in CDK4 mRNA levels through four highly conserved c-MYC binding sites within the CDK4 promoter. Cell-cycle progression is delayed in c-MYC-deficient RAT1 cells, and this delay was associated with a defect in CDK4 induction. Ectopic expression of CDK4 in these cells partially alleviated the growth defect. Thus, CDK4 provides a direct link between the oncogenic effects of c-MYC and cell-cycle regulation. | lld:pubmed |
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| pubmed-article:10688915 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10688915 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10688915 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10688915 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10688915 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10688915 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:VogelsteinBB | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:LUEE | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:DangC VCV | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:KinzlerK WKW | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:BarrettJ FJF | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:SedivyJ MJM | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:GrayF EFE | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:KohlhuberFF | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:O'ConnellB... | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:SchuhmacherMM | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:TamWW | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:HermekingHH | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:RagiEE | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:ObayaA JAJ | lld:pubmed |
| pubmed-article:10688915 | pubmed:author | pubmed-author:MateyakM KMK | lld:pubmed |
| pubmed-article:10688915 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10688915 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:10688915 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:10688915 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10688915 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10688915 | pubmed:pagination | 2229-34 | lld:pubmed |
| pubmed-article:10688915 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10688915 | pubmed:year | 2000 | lld:pubmed |
