| pubmed-article:10674880 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10674880 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:10674880 | lifeskim:mentions | umls-concept:C1516213 | lld:lifeskim |
| pubmed-article:10674880 | lifeskim:mentions | umls-concept:C0013216 | lld:lifeskim |
| pubmed-article:10674880 | lifeskim:mentions | umls-concept:C0008976 | lld:lifeskim |
| pubmed-article:10674880 | lifeskim:mentions | umls-concept:C0034656 | lld:lifeskim |
| pubmed-article:10674880 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:10674880 | lifeskim:mentions | umls-concept:C0023983 | lld:lifeskim |
| pubmed-article:10674880 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:10674880 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:10674880 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:10674880 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10674880 | pubmed:dateCreated | 2000-4-7 | lld:pubmed |
| pubmed-article:10674880 | pubmed:abstractText | A potential advantage of primary over adjuvant chemotherapy in breast cancer survival had been proposed on theoretical grounds. In 1994, early results of the S6-trial comparing primary chemotherapy vs. adjuvant chemotherapy for operable breast cancer in 390 premenopausal patients had shown significant improvement in survival of the primary chemotherapy arm (p = 0.04). An updated analysis conducted in 1995 showed the disappearance of this difference between the two arms (p = 0.18). In the present analysis, we investigated the potential short and long-term benefits attributable to primary chemotherapy by applying weighted logrank tests designed to assess specifically these effects. Results were compared to those obtained with the classical logrank test. At a median follow-up of 105 months, a significant short-term survival benefit (p = 0.02) in favor of the primary chemotherapy has been shown. However, no long-term survival benefit (p = 0.36) could be documented. The classical logrank test had revealed no significant difference (p = 0.24) between the two groups but the proportional hazard assumption being rejected (p = 0.04), the efficiency of this test can be questioned. Results using the present analysis suggested that primary chemotherapy delayed early death rates, without significantly modifying long-term event rates. It emphasizes that a short-term effect which is not necessarily associated with a long-term benefit may be seen at an early evaluation and disappear later on. | lld:pubmed |
| pubmed-article:10674880 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10674880 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10674880 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10674880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10674880 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10674880 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10674880 | pubmed:issn | 0167-6806 | lld:pubmed |
| pubmed-article:10674880 | pubmed:author | pubmed-author:PouillartPP | lld:pubmed |
| pubmed-article:10674880 | pubmed:author | pubmed-author:AsselainBB | lld:pubmed |
| pubmed-article:10674880 | pubmed:author | pubmed-author:MoreauTT | lld:pubmed |
| pubmed-article:10674880 | pubmed:author | pubmed-author:FourquetAA | lld:pubmed |
| pubmed-article:10674880 | pubmed:author | pubmed-author:de la... | lld:pubmed |
| pubmed-article:10674880 | pubmed:author | pubmed-author:SchollS MSM | lld:pubmed |
| pubmed-article:10674880 | pubmed:author | pubmed-author:BroëtPP | lld:pubmed |
| pubmed-article:10674880 | pubmed:author | pubmed-author:De RyckeYY | lld:pubmed |
| pubmed-article:10674880 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10674880 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:10674880 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10674880 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10674880 | pubmed:pagination | 151-6 | lld:pubmed |
| pubmed-article:10674880 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:10674880 | pubmed:meshHeading | pubmed-meshheading:10674880... | lld:pubmed |
| pubmed-article:10674880 | pubmed:meshHeading | pubmed-meshheading:10674880... | lld:pubmed |
| pubmed-article:10674880 | pubmed:meshHeading | pubmed-meshheading:10674880... | lld:pubmed |
| pubmed-article:10674880 | pubmed:meshHeading | pubmed-meshheading:10674880... | lld:pubmed |
| pubmed-article:10674880 | pubmed:meshHeading | pubmed-meshheading:10674880... | lld:pubmed |
| pubmed-article:10674880 | pubmed:meshHeading | pubmed-meshheading:10674880... | lld:pubmed |
| pubmed-article:10674880 | pubmed:meshHeading | pubmed-meshheading:10674880... | lld:pubmed |
| pubmed-article:10674880 | pubmed:meshHeading | pubmed-meshheading:10674880... | lld:pubmed |
| pubmed-article:10674880 | pubmed:meshHeading | pubmed-meshheading:10674880... | lld:pubmed |
| pubmed-article:10674880 | pubmed:meshHeading | pubmed-meshheading:10674880... | lld:pubmed |
| pubmed-article:10674880 | pubmed:meshHeading | pubmed-meshheading:10674880... | lld:pubmed |
| pubmed-article:10674880 | pubmed:meshHeading | pubmed-meshheading:10674880... | lld:pubmed |
| pubmed-article:10674880 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10674880 | pubmed:articleTitle | Short and long-term effects on survival in breast cancer patients treated by primary chemotherapy: an updated analysis of a randomized trial. | lld:pubmed |
| pubmed-article:10674880 | pubmed:affiliation | Department of Biostatistics, Curie Institute, Paris, France. | lld:pubmed |
| pubmed-article:10674880 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10674880 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10674880 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:10674880 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
| pubmed-article:10674880 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10674880 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10674880 | lld:pubmed |
