| pubmed-article:10658005 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10658005 | lifeskim:mentions | umls-concept:C0038317 | lld:lifeskim |
| pubmed-article:10658005 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10658005 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:10658005 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10658005 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10658005 | pubmed:dateCreated | 2000-3-3 | lld:pubmed |
| pubmed-article:10658005 | pubmed:abstractText | Habitual exercise results in a rightward shift in left ventricular end diastolic (LVED) pressure-volume or internal dimension (P-D) relationships [left ventricular (LV) remodeling]. However, exercise-mediated LV hypertrophy (LVH) produces an increased LV relative wall thickness [ratio (h/r) of wall thickness (h) to internal radius (r)] and hence a decrement in diastolic wall stress despite LV remodeling. In this study, the effect of chronic administration of an androgenic steroid on exercise-induced LV remodeling and h/r was examined in rats. Habitual exercise on voluntary running wheels resulted in LVH and a rightward shift in the LVED P-D relationships. However, LVH was sufficient to increase LVED h/r. Androgenic steroid administration to exercised rats, without influencing the development of exercise-induced LVH, produced a further rightward shift in the LVED P-D relationship associated with an increased diameter intercept. As a consequence, LVED h/r was reduced to control values. The steroid-mediated effects were not associated with alterations in either the quantity or quality of LV collagen. In conclusion, high-dose androgenic steroid administration alters exercise-induced LV remodeling and subsequently reduces the beneficial effect of physiological LVH on LV h/r. | lld:pubmed |
| pubmed-article:10658005 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10658005 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10658005 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10658005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10658005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10658005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10658005 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10658005 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10658005 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:10658005 | pubmed:author | pubmed-author:NortonG RGR | lld:pubmed |
| pubmed-article:10658005 | pubmed:author | pubmed-author:WoodiwissA... | lld:pubmed |
| pubmed-article:10658005 | pubmed:author | pubmed-author:TrifunovicBB | lld:pubmed |
| pubmed-article:10658005 | pubmed:author | pubmed-author:PhilippidesMM | lld:pubmed |
| pubmed-article:10658005 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10658005 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:10658005 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10658005 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10658005 | pubmed:pagination | 409-15 | lld:pubmed |
| pubmed-article:10658005 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:meshHeading | pubmed-meshheading:10658005... | lld:pubmed |
| pubmed-article:10658005 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10658005 | pubmed:articleTitle | Effects of an androgenic steroid on exercise-induced cardiac remodeling in rats. | lld:pubmed |
| pubmed-article:10658005 | pubmed:affiliation | Laboratory of Cardiovascular Pathophysiology, Department of Physiology, University of the Witwatersrand, 2193 Johannesburg, South Africa. | lld:pubmed |
| pubmed-article:10658005 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10658005 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
