| pubmed-article:10655494 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10655494 | lifeskim:mentions | umls-concept:C0682972 | lld:lifeskim |
| pubmed-article:10655494 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:10655494 | lifeskim:mentions | umls-concept:C1333676 | lld:lifeskim |
| pubmed-article:10655494 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:10655494 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:10655494 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:10655494 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:10655494 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10655494 | pubmed:dateCreated | 2000-3-2 | lld:pubmed |
| pubmed-article:10655494 | pubmed:abstractText | Recently, we identified a GTPase-activating protein for the ADP ribosylation factor family of small GTP-binding proteins that we call GIT1. This protein initially was identified as an interacting partner for the G protein-coupled receptor kinases, and its overexpression was found to affect signaling and internalization of the prototypical beta(2)-adrenergic receptor. Here, we report that GIT1 overexpression regulates internalization of numerous, but not all, G protein-coupled receptors. The specificity of the GIT1 effect is not related to the type of G protein to which a receptor couples, but rather to the endocytic route it uses. GIT1 only affects the function of G protein-coupled receptors that are internalized through the clathrin-coated pit pathway in a beta-arrestin- and dynamin-sensitive manner. Furthermore, the GIT1 effect is not limited to G protein-coupled receptors because overexpression of this protein also affects internalization of the epidermal growth factor receptor. However, constitutive agonist-independent internalization is not regulated by GIT1, because transferrin uptake is not affected by GIT1 overexpression. Thus, GIT1 is a protein involved in regulating the function of signaling receptors internalized through the clathrin pathway and can be used as a diagnostic tool for defining the endocytic pathway of a receptor. | lld:pubmed |
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| pubmed-article:10655494 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10655494 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10655494 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10655494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10655494 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10655494 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10655494 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10655494 | pubmed:author | pubmed-author:LefkowitzR... | lld:pubmed |
| pubmed-article:10655494 | pubmed:author | pubmed-author:WalkerJ KJK | lld:pubmed |
| pubmed-article:10655494 | pubmed:author | pubmed-author:ClaingAA | lld:pubmed |
| pubmed-article:10655494 | pubmed:author | pubmed-author:PremontR TRT | lld:pubmed |
| pubmed-article:10655494 | pubmed:author | pubmed-author:PerryS JSJ | lld:pubmed |
| pubmed-article:10655494 | pubmed:author | pubmed-author:AlbanesiJ PJP | lld:pubmed |
| pubmed-article:10655494 | pubmed:author | pubmed-author:AchiriloaieMM | lld:pubmed |
| pubmed-article:10655494 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10655494 | pubmed:day | 1 | lld:pubmed |
