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pubmed-article:10653329pubmed:abstractTextWhen term infants are fed standard formula that does not contain long-chain polyunsaturated fatty acids (LC-PUFA), they still show lower levels of docosahexaenoic acid (DHA) in red blood cell (RBC) phospholipids by several weeks or months postnatally. This study was designed in order to evaluate a potential alternative for supplementing term infant formulas with DHA by adding a high-DHA/low-eicosapentanoic acid fish oil to levels similar to that in human milk (0.3%). A total of 37 term infants were included in the study at 3 days of life. DHA concentrations remained stable between inclusion and 4 months of life at around 8% of the RBC phospholipids in the LC-PUFA enriched formula-fed group whereas it decreased significantly in the standard formula-fed group. In the human milk-fed group, RBC DHA concentrations at 4 months of age were significantly lower than that at birth and were significantly correlated with the duration of breast feeding (r = 0.85; P = 0.0002). A significant decrease of arachidonic acid between inclusion and 4 months of age was observed in the enriched formula-fed group and reached a mean value at 4 months, which was significantly lower than that observed in the human milk or standard formula-fed groups (P<0.0001). CONCLUSION: Supplementing term formulas with a high-docosahexaenoic acid/low-eicosapentanoic acid fish oil up to 4 months of age is efficient in improving docosahexaenoic acid status, however it increases the risk of impaired n-6 fatty acid status.lld:pubmed
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pubmed-article:10653329pubmed:statusMEDLINElld:pubmed
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pubmed-article:10653329pubmed:authorpubmed-author:SalleB LBLlld:pubmed
pubmed-article:10653329pubmed:authorpubmed-author:ClarisOOlld:pubmed
pubmed-article:10653329pubmed:authorpubmed-author:LapillonneAAlld:pubmed
pubmed-article:10653329pubmed:authorpubmed-author:BrossardNNlld:pubmed
pubmed-article:10653329pubmed:authorpubmed-author:ReygrobelletB...lld:pubmed
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pubmed-article:10653329pubmed:volume159lld:pubmed
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pubmed-article:10653329pubmed:pagination49-53lld:pubmed
pubmed-article:10653329pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:10653329pubmed:articleTitleErythrocyte fatty acid composition in term infants fed human milk or a formula enriched with a low eicosapentanoic acid fish oil for 4 months.lld:pubmed
pubmed-article:10653329pubmed:affiliationDepartment of Neonatology, Hopital Edouard Herriot, Lyon, France.lld:pubmed
pubmed-article:10653329pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10653329pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:10653329pubmed:publicationTypeRandomized Controlled Triallld:pubmed
pubmed-article:10653329pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed