| pubmed-article:10650002 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10650002 | lifeskim:mentions | umls-concept:C0038435 | lld:lifeskim |
| pubmed-article:10650002 | lifeskim:mentions | umls-concept:C0021699 | lld:lifeskim |
| pubmed-article:10650002 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:10650002 | lifeskim:mentions | umls-concept:C1367731 | lld:lifeskim |
| pubmed-article:10650002 | lifeskim:mentions | umls-concept:C1150587 | lld:lifeskim |
| pubmed-article:10650002 | lifeskim:mentions | umls-concept:C1705632 | lld:lifeskim |
| pubmed-article:10650002 | lifeskim:mentions | umls-concept:C1414444 | lld:lifeskim |
| pubmed-article:10650002 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:10650002 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10650002 | pubmed:issue | 5453 | lld:pubmed |
| pubmed-article:10650002 | pubmed:dateCreated | 2000-2-18 | lld:pubmed |
| pubmed-article:10650002 | pubmed:abstractText | Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which activate chaperone genes in response to ER stress, also activated JNK, and IRE1alpha-/- fibroblasts were impaired in JNK activation by ER stress. The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. Dominant-negative TRAF2 inhibited activation of JNK by IRE1. Activation of JNK by endogenous signals initiated in the ER proceeds by a pathway similar to that initiated by cell surface receptors in response to extracellular signals. | lld:pubmed |
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| pubmed-article:10650002 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10650002 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10650002 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10650002 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:10650002 | pubmed:author | pubmed-author:RoyII | lld:pubmed |
| pubmed-article:10650002 | pubmed:author | pubmed-author:ChungPP | lld:pubmed |
| pubmed-article:10650002 | pubmed:author | pubmed-author:BertolottiAA | lld:pubmed |
| pubmed-article:10650002 | pubmed:author | pubmed-author:ZhangYY | lld:pubmed |
| pubmed-article:10650002 | pubmed:author | pubmed-author:WangXX | lld:pubmed |
| pubmed-article:10650002 | pubmed:author | pubmed-author:UranoFF | lld:pubmed |
| pubmed-article:10650002 | pubmed:author | pubmed-author:HardingH PHP | lld:pubmed |
| pubmed-article:10650002 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10650002 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:10650002 | pubmed:volume | 287 | lld:pubmed |
| pubmed-article:10650002 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10650002 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10650002 | pubmed:pagination | 664-6 | lld:pubmed |
| pubmed-article:10650002 | pubmed:dateRevised | 2010-5-21 | lld:pubmed |
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| pubmed-article:10650002 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10650002 | pubmed:articleTitle | Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. | lld:pubmed |
| pubmed-article:10650002 | pubmed:affiliation | Skirball Institute of Biomolecular Medicine, Departments of Medicine, Cell Biology and the Kaplan Cancer Center, New York University Medical School, New York, NY 10016, USA. | lld:pubmed |
| pubmed-article:10650002 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10650002 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10650002 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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