| pubmed-article:10647998 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10647998 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:10647998 | lifeskim:mentions | umls-concept:C1705593 | lld:lifeskim |
| pubmed-article:10647998 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:10647998 | lifeskim:mentions | umls-concept:C1332652 | lld:lifeskim |
| pubmed-article:10647998 | lifeskim:mentions | umls-concept:C0065904 | lld:lifeskim |
| pubmed-article:10647998 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10647998 | lifeskim:mentions | umls-concept:C0812445 | lld:lifeskim |
| pubmed-article:10647998 | lifeskim:mentions | umls-concept:C0120324 | lld:lifeskim |
| pubmed-article:10647998 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10647998 | pubmed:dateCreated | 2000-2-9 | lld:pubmed |
| pubmed-article:10647998 | pubmed:abstractText | Continuous expression of the MGSA/GROalpha, beta, or gamma chemokine bestows tumor-forming capacity to the immortalized murine melanocyte cell line, melan-a. The mechanism for this transformation is unclear, although both autocrine and paracrine processes are possible because melan-a cells as well as endothelial cells express a low level of the receptor for this ligand. To further define the role of MGSA/GRO proteins in melanocyte transformation, two types of experiments were designed to neutralize the biological effects of MGSA/GRO in the transfected melan-a clones: (1) the effect of neutralizing antiserum to MGSA/GRO proteins on melan-a tumor growth was assessed; (2) the tumor-forming capacity of melan-a clones expressing ELR motif-mutated forms of MGSA/GRO with compromised receptor affinity was compared to the tumor-forming capacity of clones expressing wild-type MGSA/GRO. These experiments revealed that SCID mice inoculated with MGSA/GROalpha- or gamma-expressing melan-a cells and subsequently treated with antiserum to the respective chemokine exhibited decreased tumor growth. This reduction in tumor growth was accompanied by declining angiogenic activity in MGSA/GROgamma-expressing tumors. Moreover, athymic nude mice injected with melan-a cells expressing ELR-mutant forms of MGSA/GROalpha exhibited markedly impaired tumor-forming capacity compared with those mice injected with melan-a clones expressing wild-type MGSA/GRO. These data suggest that continuous expression of MGSA/GRO proteins may facilitate tumor growth by stimulating the growth of microvessels into the tumor (paracrine) and by affecting melanocyte growth (autocrine). | lld:pubmed |
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| pubmed-article:10647998 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10647998 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10647998 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10647998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10647998 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10647998 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10647998 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:10647998 | pubmed:author | pubmed-author:WangDD | lld:pubmed |
| pubmed-article:10647998 | pubmed:author | pubmed-author:EMSS | lld:pubmed |
| pubmed-article:10647998 | pubmed:author | pubmed-author:StrieterR MRM | lld:pubmed |
| pubmed-article:10647998 | pubmed:author | pubmed-author:RichmondAA | lld:pubmed |
| pubmed-article:10647998 | pubmed:author | pubmed-author:NanneyL BLB | lld:pubmed |
| pubmed-article:10647998 | pubmed:author | pubmed-author:LuanJJ | lld:pubmed |
| pubmed-article:10647998 | pubmed:author | pubmed-author:BurdickM DMD | lld:pubmed |
| pubmed-article:10647998 | pubmed:author | pubmed-author:HaghnegahdarH... | lld:pubmed |
| pubmed-article:10647998 | pubmed:author | pubmed-author:Shattuck-Bran... | lld:pubmed |
| pubmed-article:10647998 | pubmed:author | pubmed-author:CardwellNN | lld:pubmed |
| pubmed-article:10647998 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10647998 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:10647998 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10647998 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10647998 | pubmed:pagination | 53-62 | lld:pubmed |
| pubmed-article:10647998 | pubmed:dateRevised | 2011-5-5 | lld:pubmed |
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| pubmed-article:10647998 | pubmed:meshHeading | pubmed-meshheading:10647998... | lld:pubmed |
| pubmed-article:10647998 | pubmed:meshHeading | pubmed-meshheading:10647998... | lld:pubmed |
| pubmed-article:10647998 | pubmed:meshHeading | pubmed-meshheading:10647998... | lld:pubmed |
| pubmed-article:10647998 | pubmed:meshHeading | pubmed-meshheading:10647998... | lld:pubmed |
| pubmed-article:10647998 | pubmed:meshHeading | pubmed-meshheading:10647998... | lld:pubmed |
| pubmed-article:10647998 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10647998 | pubmed:articleTitle | The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma. | lld:pubmed |
| pubmed-article:10647998 | pubmed:affiliation | Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. | lld:pubmed |
| pubmed-article:10647998 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10647998 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
