| pubmed-article:10646508 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10646508 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10646508 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:10646508 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:10646508 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:10646508 | lifeskim:mentions | umls-concept:C0600388 | lld:lifeskim |
| pubmed-article:10646508 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:10646508 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10646508 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10646508 | pubmed:dateCreated | 2000-2-10 | lld:pubmed |
| pubmed-article:10646508 | pubmed:abstractText | In previous studies we found that mu-opioids, acting via mu-opioid receptors, inhibit endothelin-stimulated C6 glioma cell growth. In the preceding article we show that the kappa-selective opioid agonist U69,593 acts as a mitogen with a potency similar to that of endothelin in the same astrocytic model system. Here we report that C6 cell treatment with mu-opioid agonists for 1 h results in the inhibition of kappa-opioid mitogenic signaling. The mu-selective agonist endomorphin-1 attenuates kappa-opioid-stimulated DNA synthesis, phosphoinositide turnover, and extracellular signal-regulated kinase phosphorylation. To investigate the role of receptor endocytosis in signaling, we have examined the effects of dynamin-1 and its GTPase-defective, dominant suppressor mutant (K44A) on opioid modulation of extracellular signal-regulated kinase phosphorylation in C6 cells. Overexpression of dynamin K44A in C6 cells does not affect kappa-opioid phosphorylation of extracellular signal-regulated kinase. However, it does block the inhibitory action on kappa-opioid signaling mediated by the kappa-opioid receptor. Our results are consistent with a growing body of evidence of the opposing actions of mu- and kappa-opioids and provide new insight into the role of opioid receptor trafficking in signaling. | lld:pubmed |
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| pubmed-article:10646508 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10646508 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10646508 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10646508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10646508 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10646508 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10646508 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:10646508 | pubmed:author | pubmed-author:CosciaC JCJ | lld:pubmed |
| pubmed-article:10646508 | pubmed:author | pubmed-author:BelchevaM MMM | lld:pubmed |
| pubmed-article:10646508 | pubmed:author | pubmed-author:BohnL MLM | lld:pubmed |
| pubmed-article:10646508 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10646508 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:10646508 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10646508 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10646508 | pubmed:pagination | 574-81 | lld:pubmed |
| pubmed-article:10646508 | pubmed:dateRevised | 2010-1-4 | lld:pubmed |
| pubmed-article:10646508 | pubmed:meshHeading | pubmed-meshheading:10646508... | lld:pubmed |
| pubmed-article:10646508 | pubmed:meshHeading | pubmed-meshheading:10646508... | lld:pubmed |
| pubmed-article:10646508 | pubmed:meshHeading | pubmed-meshheading:10646508... | lld:pubmed |
| pubmed-article:10646508 | pubmed:meshHeading | pubmed-meshheading:10646508... | lld:pubmed |
| pubmed-article:10646508 | pubmed:meshHeading | pubmed-meshheading:10646508... | lld:pubmed |
