Linked Life Data

10645269

Source:http://linkedlifedata.com/resource/pubmed/id/10645269

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pubmed-article:10645269pubmed:abstractTextIt is generally accepted that mammalian spermatozoa undergo biochemical and morphological changes during epididymal transit, collectively termed epididymal maturation. Although many details of the biochemical modification are not fully understood, lectin binding studies from several laboratories strongly suggest that glycan moieties of sperm plasma membrane glycoproteins are extensively modified as spermatozoa transit from the proximal to the distal epididymis. In the present article, we summarize our studies with two sets of glycan modifying enzymes, namely glycosyltransferases (synthetic enzymes) and glycosidases (hydrolytic enzymes) in rat spermatozoa collected from different regions of the epididymis, and similar enzyme activities present in the epididymal luminal fluid. Our data show that the activities of these enzyme are high in the epididymal luminal fluid (> 80% of the total enzyme activities was in the plasma). Evidence presented in this report also demonstrates that: (1) at least one sperm surface glycoprotein (apparent molecular mass of 86 kDa) is fucosylated in vitro when caput spermatozoa are incubated with GDP [14C]fucose; and (2) a peanut agglutinin (PNA)-positive glycoprotein of 135-150 kDa present on plasma membrane of sperm from the caput (but not cauda) epididymidis is degalactosylated by digestion with purified luminal fluid beta-D-galactosidase. Taken together, these results strongly suggest a role for glycoprotein modifying enzymes in the modification of sperm surface glycoproteins during epididymal maturation.lld:pubmed
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pubmed-article:10645269pubmed:authorpubmed-author:TulsianiD RDRlld:pubmed
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pubmed-article:10645269pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:10645269pubmed:articleTitleRole of luminal fluid glycosyltransferases and glycosidases in the modification of rat sperm plasma membrane glycoproteins during epididymal maturation.lld:pubmed
pubmed-article:10645269pubmed:affiliationCenter for Reproductive Biology Research, Vanderbilt University School of Medicine, Nashville, TN 37232-2633, USA.lld:pubmed
pubmed-article:10645269pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10645269pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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