| pubmed-article:10644358 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10644358 | lifeskim:mentions | umls-concept:C0079337 | lld:lifeskim |
| pubmed-article:10644358 | lifeskim:mentions | umls-concept:C1819995 | lld:lifeskim |
| pubmed-article:10644358 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10644358 | lifeskim:mentions | umls-concept:C0349506 | lld:lifeskim |
| pubmed-article:10644358 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:10644358 | lifeskim:mentions | umls-concept:C0242732 | lld:lifeskim |
| pubmed-article:10644358 | lifeskim:mentions | umls-concept:C0332282 | lld:lifeskim |
| pubmed-article:10644358 | lifeskim:mentions | umls-concept:C1709474 | lld:lifeskim |
| pubmed-article:10644358 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:10644358 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:10644358 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10644358 | pubmed:dateCreated | 2000-3-2 | lld:pubmed |
| pubmed-article:10644358 | pubmed:abstractText | A cytopathic variant of feline immunodeficiency virus (FIV) strain PPR emerged after passage of wild-type virus on an interleukin-2-independent cell line. The virus, termed FIV-PPRglial, displayed a phenotype markedly different from the parental virus, including the ability to productively infect previously refractory cell lines, induction of large syncytia, and accelerated kinetic properties. A chimeric molecular clone, FIV-PPRchim42, containing the FIV-PPRglial envelope within the backbone of FIV-PPR, exhibited all the characteristics of the FIV-PPRglial phenotype, demonstrating that the viral envelope was responsible for the acquired traits. Subsequent molecular characterization revealed that the FIV-PPRglial envelope contained five amino acid substitutions relative to wild-type FIV-PPR. Mutagenic analyses further demonstrated that the acquired phenotype was minimally attributable to a combination of three mutations, specifically, a glutamine-to-proline change within the second constant domain of the surface protein (SU); a threonine-to-proline change within the V4 loop, also in the SU; and a premature stop codon in the cytoplasmic tail of the transmembrane protein. All three changes were required to produce the FIV-PPRglial phenotype. Cotransfection studies with mutant viruses in combination with each other and with FIV-PPR indicated that the truncated cytoplasmic tail was responsible for the induction of syncytium formation. Receptor usage analyses were pursued, and distinctions were observed between FIV-PPR and FIV-PPRglial. In vitro infections with FIV-PPR, FIV-PPRglial, and FIV-34TF10 on two adherent cell lines were ablated in the presence of SDF1alpha, the natural ligand for CXCR4. In contrast, viral infection of T cells was not limited to CXCR4 usage, and inhibition studies indicate the potential involvement of a CC chemokine receptor. | lld:pubmed |
| pubmed-article:10644358 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10644358 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10644358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644358 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10644358 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10644358 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:10644358 | pubmed:author | pubmed-author:ElderJ HJH | lld:pubmed |
| pubmed-article:10644358 | pubmed:author | pubmed-author:LernerD LDL | lld:pubmed |
| pubmed-article:10644358 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10644358 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:10644358 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10644358 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10644358 | pubmed:pagination | 1854-63 | lld:pubmed |
| pubmed-article:10644358 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10644358 | pubmed:meshHeading | pubmed-meshheading:10644358... | lld:pubmed |
| pubmed-article:10644358 | pubmed:meshHeading | pubmed-meshheading:10644358... | lld:pubmed |
| pubmed-article:10644358 | pubmed:meshHeading | pubmed-meshheading:10644358... | lld:pubmed |
| pubmed-article:10644358 | pubmed:meshHeading | pubmed-meshheading:10644358... | lld:pubmed |
