| pubmed-article:10644054 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10644054 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:10644054 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10644054 | lifeskim:mentions | umls-concept:C0000970 | lld:lifeskim |
| pubmed-article:10644054 | lifeskim:mentions | umls-concept:C0001962 | lld:lifeskim |
| pubmed-article:10644054 | lifeskim:mentions | umls-concept:C0041165 | lld:lifeskim |
| pubmed-article:10644054 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:10644054 | lifeskim:mentions | umls-concept:C0235378 | lld:lifeskim |
| pubmed-article:10644054 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:10644054 | lifeskim:mentions | umls-concept:C0064032 | lld:lifeskim |
| pubmed-article:10644054 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10644054 | pubmed:dateCreated | 2000-2-3 | lld:pubmed |
| pubmed-article:10644054 | pubmed:abstractText | Ethanol and isopentanol are the predominant alcohols in alcoholic beverages. We have reported previously that pretreatment of rats with a liquid diet containing 6.3% ethanol plus 0.5% isopentanol for 7 days results in a synergistic increase in acetaminophen hepatotoxicity, compared with rats treated with either alcohol alone. Here, we investigated the role of CYP3A in acetaminophen hepatotoxicity associated with the combined alcohol treatment. Triacetyloleandomycin, a specific inhibitor of CYP3A, protected rats pretreated with ethanol along with isopentanol from acetaminophen hepatotoxicity. At both 0.25 and 0.5 g acetaminophen/kg, triacetyloleandomycin partially prevented elevations in serum levels of alanine aminotransferase. At 0.25 g acetaminophen/kg, triacetyloleandomycin completely protected 6 of 8 rats from histologically observed liver damage, and partially protected the remaining 2 rats. At 0.5 g acetaminophen/kg, triacetyloleandomycin decreased histologically observed liver damage in 7 of 15 rats. In rats pretreated with ethanol plus isopentanol, CYP3A, measured immunohistochemically, was decreased by acetaminophen treatment. This effect was prevented by triacetyloleandomycin. These results suggest that CYP3A has a major role in acetaminophen hepatotoxicity in animals administered the combined alcohol treatment. We also found that exposure to ethanol along with 0.1% isopentanol for only 3 days resulted in maximal increases in acetaminophen hepatotoxicity by the combined alcohol treatment, suggesting that short-term consumption of alcoholic beverages rich in isopentanol may be a risk for developing liver damage from acetaminophen. | lld:pubmed |
| pubmed-article:10644054 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10644054 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644054 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10644054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10644054 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10644054 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10644054 | pubmed:issn | 0006-2952 | lld:pubmed |
| pubmed-article:10644054 | pubmed:author | pubmed-author:WongS SSS | lld:pubmed |
| pubmed-article:10644054 | pubmed:author | pubmed-author:JefferyE HEH | lld:pubmed |
| pubmed-article:10644054 | pubmed:author | pubmed-author:WrightonS ASA | lld:pubmed |
| pubmed-article:10644054 | pubmed:author | pubmed-author:WrightDD | lld:pubmed |
| pubmed-article:10644054 | pubmed:author | pubmed-author:SinclairP RPR | lld:pubmed |
| pubmed-article:10644054 | pubmed:author | pubmed-author:SinclairJ FJF | lld:pubmed |
| pubmed-article:10644054 | pubmed:author | pubmed-author:BementW JWJ | lld:pubmed |
| pubmed-article:10644054 | pubmed:author | pubmed-author:SzakacsJ GJG | lld:pubmed |
| pubmed-article:10644054 | pubmed:author | pubmed-author:KostrubskyV... | lld:pubmed |
| pubmed-article:10644054 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10644054 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10644054 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:10644054 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10644054 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10644054 | pubmed:pagination | 445-54 | lld:pubmed |
| pubmed-article:10644054 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10644054 | pubmed:meshHeading | pubmed-meshheading:10644054... | lld:pubmed |
| pubmed-article:10644054 | pubmed:meshHeading | pubmed-meshheading:10644054... | lld:pubmed |
| pubmed-article:10644054 | pubmed:meshHeading | pubmed-meshheading:10644054... | lld:pubmed |
| pubmed-article:10644054 | pubmed:meshHeading | pubmed-meshheading:10644054... | lld:pubmed |
| pubmed-article:10644054 | pubmed:meshHeading | pubmed-meshheading:10644054... | lld:pubmed |
| pubmed-article:10644054 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10644054 | pubmed:articleTitle | Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: protection by triacetyloleandomycin. | lld:pubmed |
| pubmed-article:10644054 | pubmed:affiliation | Veterans Administration Medical Center, White River Junction, VT 05009, USA. JSINC@dartmouth.edu | lld:pubmed |
| pubmed-article:10644054 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10644054 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10644054 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10644054 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10644054 | lld:pubmed |
