| pubmed-article:10643872 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10643872 | lifeskim:mentions | umls-concept:C0680063 | lld:lifeskim |
| pubmed-article:10643872 | lifeskim:mentions | umls-concept:C0024554 | lld:lifeskim |
| pubmed-article:10643872 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10643872 | lifeskim:mentions | umls-concept:C1261210 | lld:lifeskim |
| pubmed-article:10643872 | lifeskim:mentions | umls-concept:C0012052 | lld:lifeskim |
| pubmed-article:10643872 | lifeskim:mentions | umls-concept:C0878751 | lld:lifeskim |
| pubmed-article:10643872 | lifeskim:mentions | umls-concept:C0879626 | lld:lifeskim |
| pubmed-article:10643872 | lifeskim:mentions | umls-concept:C0010339 | lld:lifeskim |
| pubmed-article:10643872 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:10643872 | lifeskim:mentions | umls-concept:C1442162 | lld:lifeskim |
| pubmed-article:10643872 | lifeskim:mentions | umls-concept:C1550718 | lld:lifeskim |
| pubmed-article:10643872 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10643872 | pubmed:dateCreated | 2000-2-3 | lld:pubmed |
| pubmed-article:10643872 | pubmed:abstractText | The objective of this study was to determine the susceptible days for the adverse effects of di-n-butyl phthalate (DBP) on development of reproductive system in male offspring following maternal administration on successive 3-day period during late pregnancy. Pregnant rats were given DBP by gastric intubation at 1000 or 1500 mg/kg on days 12-14 or 18-20 of pregnancy or at 500, 1000 or 1500 mg/kg on days 15-17 of pregnancy. A significant decrease in the maternal body weight gain and/or food consumption was found in the DBP-treated groups regardless of the days on which DBP at 1000 and 1500 mg/kg was given. A significant increase in the number of resorptions per litter was found in the groups given DBP at 1500 mg/kg on days 12-14 and 15-17 of pregnancy. The weights of male and female fetuses were significantly decreased in the groups given DBP at 1000 and 1500 mg/kg on days 12-14 and 18-20 and at 1500 mg/kg on days 15-17. A significant increase in the incidence of fetuses with undescended testes was found at 1500 mg/kg on days 12-14 and at all doses on days 15-17. A significant decrease in the anogenital distance (AGD) of male fetuses was observed in the groups treated with DBP regardless of the days of treatment. The AGD/body weight ratio in male fetuses was significantly reduced in the groups given DBP on days 15-17, but neither on days 12-14 nor 18-20. The AGD of female fetuses in the DBP-treated groups was comparable to that in the control group. It was concluded that period of days 15-17 of pregnancy was the most susceptible for DBP-induced undescended testes and decreased AGD in male offspring. | lld:pubmed |
| pubmed-article:10643872 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10643872 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10643872 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10643872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10643872 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10643872 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10643872 | pubmed:issn | 0378-4274 | lld:pubmed |
| pubmed-article:10643872 | pubmed:author | pubmed-author:KawashimaKK | lld:pubmed |
| pubmed-article:10643872 | pubmed:author | pubmed-author:FOGJJ | lld:pubmed |
| pubmed-article:10643872 | pubmed:author | pubmed-author:MiyawakiEE | lld:pubmed |
| pubmed-article:10643872 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10643872 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:10643872 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:10643872 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10643872 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10643872 | pubmed:pagination | 271-8 | lld:pubmed |
| pubmed-article:10643872 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10643872 | pubmed:meshHeading | pubmed-meshheading:10643872... | lld:pubmed |
| pubmed-article:10643872 | pubmed:meshHeading | pubmed-meshheading:10643872... | lld:pubmed |
| pubmed-article:10643872 | pubmed:meshHeading | pubmed-meshheading:10643872... | lld:pubmed |
| pubmed-article:10643872 | pubmed:meshHeading | pubmed-meshheading:10643872... | lld:pubmed |
| pubmed-article:10643872 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10643872 | pubmed:articleTitle | Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy. | lld:pubmed |
| pubmed-article:10643872 | pubmed:affiliation | National Institute of Health Sciences, Osaka Branch, Japan. ema@nihs.go.jp | lld:pubmed |
| pubmed-article:10643872 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10643872 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10643872 | lld:pubmed |
