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| pubmed-article:10642730 | lifeskim:mentions | umls-concept:C0009170 | lld:lifeskim |
| pubmed-article:10642730 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:10642730 | lifeskim:mentions | umls-concept:C0026607 | lld:lifeskim |
| pubmed-article:10642730 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:10642730 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:10642730 | lifeskim:mentions | umls-concept:C0234621 | lld:lifeskim |
| pubmed-article:10642730 | lifeskim:mentions | umls-concept:C0376335 | lld:lifeskim |
| pubmed-article:10642730 | lifeskim:mentions | umls-concept:C0442726 | lld:lifeskim |
| pubmed-article:10642730 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:10642730 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:10642730 | lifeskim:mentions | umls-concept:C1707489 | lld:lifeskim |
| pubmed-article:10642730 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10642730 | pubmed:dateCreated | 2000-3-14 | lld:pubmed |
| pubmed-article:10642730 | pubmed:abstractText | Functional magnetic resonance imaging (fMRI) was conducted to observe the effects of cocaine administration on the physiological fluctuations of fMRI signal in two brain regions. Seven long-term cocaine users with an average age of 32 years and 8 years of cocaine use history were recruited for the study. A T2*-weighted fast echo-planar imaging (EPI) pulse sequence was employed at 1.5 T to acquire three sets of brain images for each subject under three conditions (at rest, after saline injection, and after cocaine injection [0.57 mg/kg]). Cross-correlation maps were constructed using the synchronous, low frequency signal from voxel time courses after filtering respiratory, cardiac, and other physiological noise. A quantitative evaluation of the changes in functional connectivity was made using spatial correlation coefficient (SCC) analysis. A marked 50% reduction in SCC values in the region of primary visual cortex and 43% reduction in SCC values in the region of primary motor cortex were observed after cocaine administration. This significant reduction in SCC values in these cortical regions is a reflection of changes in neuronal activity. It is suggested that the observed changes in low frequency components after acute cocaine administration during a resting, no-task situation may be used as a baseline reference source when assessing the effects of cocaine on task-driven activation or on mesolimbic dopamine pathways. | lld:pubmed |
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| pubmed-article:10642730 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10642730 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10642730 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10642730 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10642730 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10642730 | pubmed:issn | 0740-3194 | lld:pubmed |
| pubmed-article:10642730 | pubmed:author | pubmed-author:SteinE AEA | lld:pubmed |
| pubmed-article:10642730 | pubmed:author | pubmed-author:RainerJJ | lld:pubmed |
| pubmed-article:10642730 | pubmed:author | pubmed-author:MASS | lld:pubmed |
| pubmed-article:10642730 | pubmed:author | pubmed-author:LaoR SRS | lld:pubmed |
| pubmed-article:10642730 | pubmed:author | pubmed-author:LiS JSJ | lld:pubmed |
| pubmed-article:10642730 | pubmed:author | pubmed-author:BiswalBB | lld:pubmed |
| pubmed-article:10642730 | pubmed:author | pubmed-author:RisingerRR | lld:pubmed |
| pubmed-article:10642730 | pubmed:author | pubmed-author:SalmeronB JBJ | lld:pubmed |
| pubmed-article:10642730 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10642730 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:10642730 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10642730 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10642730 | pubmed:pagination | 45-51 | lld:pubmed |
| pubmed-article:10642730 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10642730 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10642730 | pubmed:articleTitle | Cocaine administration decreases functional connectivity in human primary visual and motor cortex as detected by functional MRI. | lld:pubmed |
| pubmed-article:10642730 | pubmed:affiliation | Biophysics Research Institute, Medical College of Wisconsin, Milwaukee 53226, USA. sjli@mcw.edu | lld:pubmed |
| pubmed-article:10642730 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10642730 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10642730 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10642730 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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