| pubmed-article:10640741 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10640741 | lifeskim:mentions | umls-concept:C0027836 | lld:lifeskim |
| pubmed-article:10640741 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:10640741 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10640741 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:10640741 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:10640741 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10640741 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10640741 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10640741 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10640741 | pubmed:dateCreated | 2000-2-24 | lld:pubmed |
| pubmed-article:10640741 | pubmed:abstractText | Fas/Apo-1 is a member of the TNF receptor superfamily that signals apoptotic cell death in susceptible target cells. Fas or Fas ligand (FasL)-deficient mice are relatively resistant to the induction of experimental allergic encephalomyelitis, implying the involvement of Fas/FasL in this disease process. We have examined the regulation and function of Fas expression in glial cells (astrocytes and microglia). Fas is constitutively expressed by primary murine microglia at a low level and significantly up-regulated by TNF-alpha or IFN-gamma stimulation. Primary astrocytes express high constitutive levels of Fas, which are not further affected by cytokine treatment. In microglia, Fas expression is regulated at the level of mRNA expression; TNF-alpha and IFN-gamma induced Fas mRNA by approximately 20-fold. STAT-1alpha and NF-kappaB activation are involved in IFN-gamma- or TNF-alpha-mediated Fas up-regulation in microglia, respectively. The cytokine TGF-beta inhibits basal expression of Fas as well as cytokine-mediated Fas expression by microglia. Upon incubation of microglial cells with FasL-expressing cells, approximately 20% of cells underwent Fas-mediated cell death, which increased to approximately 60% when cells were pretreated with either TNF-alpha or IFN-gamma. TGF-beta treatment inhibited Fas-mediated cell death of TNF-alpha- or IFN-gamma-stimulated microglial cells. In contrast, astrocytes are resistant to Fas-mediated cell death, however, ligation of Fas induces expression of the chemokines macrophage inflammatory protein-1beta (MIP-1beta), MIP-1alpha, and MIP-2. These data demonstrate that Fas transmits different signals in the two glial cell populations: a cytotoxic signal in microglia and an inflammatory signal in the astrocyte. | lld:pubmed |
| pubmed-article:10640741 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10640741 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10640741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10640741 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10640741 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10640741 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10640741 | pubmed:author | pubmed-author:LeeS JSJ | lld:pubmed |
| pubmed-article:10640741 | pubmed:author | pubmed-author:WangZZ | lld:pubmed |
| pubmed-article:10640741 | pubmed:author | pubmed-author:ZhouTT | lld:pubmed |
| pubmed-article:10640741 | pubmed:author | pubmed-author:ChoiCC | lld:pubmed |
| pubmed-article:10640741 | pubmed:author | pubmed-author:BenvenisteE... | lld:pubmed |
| pubmed-article:10640741 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10640741 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10640741 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:10640741 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10640741 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10640741 | pubmed:pagination | 1277-85 | lld:pubmed |
| pubmed-article:10640741 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:meshHeading | pubmed-meshheading:10640741... | lld:pubmed |
| pubmed-article:10640741 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10640741 | pubmed:articleTitle | Differential regulation and function of Fas expression on glial cells. | lld:pubmed |
| pubmed-article:10640741 | pubmed:affiliation | Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. | lld:pubmed |
| pubmed-article:10640741 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10640741 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10640741 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10640741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10640741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10640741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10640741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10640741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10640741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10640741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10640741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10640741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10640741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10640741 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10640741 | lld:pubmed |
