| pubmed-article:10639328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10639328 | lifeskim:mentions | umls-concept:C0038435 | lld:lifeskim |
| pubmed-article:10639328 | lifeskim:mentions | umls-concept:C0027834 | lld:lifeskim |
| pubmed-article:10639328 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:10639328 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10639328 | lifeskim:mentions | umls-concept:C1420192 | lld:lifeskim |
| pubmed-article:10639328 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10639328 | pubmed:dateCreated | 2000-4-24 | lld:pubmed |
| pubmed-article:10639328 | pubmed:abstractText | Neurofilaments comprise three subunit proteins; neurofilament light, middle and heavy chains (NF-L, NF-M and NF-H). The carboxy-terminal domains of NF-M and NF-H form side-arms that project from the filament and that of NF-H contains multiple repeats of the motif lys-ser-pro, the serines of which are targets for phosphorylation. The level of phosphorylation on the lys-ser-pro repeats varies topographically within the cell; in cell bodies and proximal axons, the side-arms are largely non-phosphorylated whereas in more distal regions of axons, the side-arms are heavily phosphorylated. Here we show that stress activated protein kinase 1b (SAPK1b), a major SAPK in neurones will phosphorylate NF-H side-arms both in vitro and in transfected cells. These studies suggest that SAPK1b targets multiple phosphorylation sites within NF-H side-arms. Additionally, we show that glutamate treatment induces activation of SAPK1b in primary cortical neurones and increased phosphorylation of NF-H in cell bodies. This suggests that glutamate causes increased NF-H phosphorylation at least in part by activation of stress activated protein kinases. | lld:pubmed |
| pubmed-article:10639328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10639328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10639328 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10639328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10639328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10639328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10639328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10639328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10639328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10639328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10639328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10639328 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10639328 | pubmed:issn | 0021-9533 | lld:pubmed |
| pubmed-article:10639328 | pubmed:author | pubmed-author:LeighP NPN | lld:pubmed |
| pubmed-article:10639328 | pubmed:author | pubmed-author:DavisDD | lld:pubmed |
| pubmed-article:10639328 | pubmed:author | pubmed-author:YatesAA | lld:pubmed |
| pubmed-article:10639328 | pubmed:author | pubmed-author:AndertonB HBH | lld:pubmed |
| pubmed-article:10639328 | pubmed:author | pubmed-author:MillerC CCC | lld:pubmed |
| pubmed-article:10639328 | pubmed:author | pubmed-author:ShawC ECE | lld:pubmed |
| pubmed-article:10639328 | pubmed:author | pubmed-author:BrownleesJJ | lld:pubmed |
| pubmed-article:10639328 | pubmed:author | pubmed-author:BajajN PNP | lld:pubmed |
| pubmed-article:10639328 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10639328 | pubmed:volume | 113 ( Pt 3) | lld:pubmed |
| pubmed-article:10639328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10639328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10639328 | pubmed:pagination | 401-7 | lld:pubmed |
| pubmed-article:10639328 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10639328 | pubmed:meshHeading | pubmed-meshheading:10639328... | lld:pubmed |
| pubmed-article:10639328 | pubmed:meshHeading | pubmed-meshheading:10639328... | lld:pubmed |
| pubmed-article:10639328 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10639328 | pubmed:articleTitle | Phosphorylation of neurofilament heavy chain side-arms by stress activated protein kinase-1b/Jun N-terminal kinase-3. | lld:pubmed |
| pubmed-article:10639328 | pubmed:affiliation | Department of Neuroscience, The Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK. | lld:pubmed |
| pubmed-article:10639328 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10639328 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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