| pubmed-article:10628903 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10628903 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:10628903 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10628903 | lifeskim:mentions | umls-concept:C0024778 | lld:lifeskim |
| pubmed-article:10628903 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:10628903 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:10628903 | lifeskim:mentions | umls-concept:C1979963 | lld:lifeskim |
| pubmed-article:10628903 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:10628903 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10628903 | pubmed:dateCreated | 2000-1-20 | lld:pubmed |
| pubmed-article:10628903 | pubmed:abstractText | The aim of the present study was to examine the toxic effects of single oral administrations of the antidepressant maprotiline at 150 mg/kg or 300 mg/kg using female Sprague-Dawley rats. Body-weight gain was significantly reduced in the group receiving 300 mg/kg on days 1-5 of the study (P<0.01). A significant reduction in food and water intake was observed on days 1 and 2 of the study (P<0.01) in the 300 mg/kg group and on day 1 in the 150 mg/kg group (P<0.05). There was a significant decrease in nocturnal home cage activity over the first five days of the study in the 300 mg/kg group (P<0.01). A significant hypothermic response was observed in both 150 and 300 mg/kg groups at 1, 2 and 4 hr after dosing (P<0.01), that had returned to control values within 8 hr following administration. This study demonstrates that a multi-parameter approach is appropriate for the investigation of high doses of antidepressants in rodents. | lld:pubmed |
| pubmed-article:10628903 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10628903 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10628903 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10628903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10628903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10628903 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10628903 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10628903 | pubmed:issn | 0901-9928 | lld:pubmed |
| pubmed-article:10628903 | pubmed:author | pubmed-author:LeonardB EBE | lld:pubmed |
| pubmed-article:10628903 | pubmed:author | pubmed-author:KellyJ PJP | lld:pubmed |
| pubmed-article:10628903 | pubmed:author | pubmed-author:ChambersP LPL | lld:pubmed |
| pubmed-article:10628903 | pubmed:author | pubmed-author:DardeMM | lld:pubmed |
| pubmed-article:10628903 | pubmed:author | pubmed-author:DredgeKK | lld:pubmed |
| pubmed-article:10628903 | pubmed:author | pubmed-author:KellehirPP | lld:pubmed |
| pubmed-article:10628903 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10628903 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:10628903 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10628903 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10628903 | pubmed:pagination | 276-81 | lld:pubmed |
| pubmed-article:10628903 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:10628903 | pubmed:meshHeading | pubmed-meshheading:10628903... | lld:pubmed |
| pubmed-article:10628903 | pubmed:meshHeading | pubmed-meshheading:10628903... | lld:pubmed |
| pubmed-article:10628903 | pubmed:meshHeading | pubmed-meshheading:10628903... | lld:pubmed |
| pubmed-article:10628903 | pubmed:meshHeading | pubmed-meshheading:10628903... | lld:pubmed |
| pubmed-article:10628903 | pubmed:meshHeading | pubmed-meshheading:10628903... | lld:pubmed |
| pubmed-article:10628903 | pubmed:meshHeading | pubmed-meshheading:10628903... | lld:pubmed |
| pubmed-article:10628903 | pubmed:meshHeading | pubmed-meshheading:10628903... | lld:pubmed |
| pubmed-article:10628903 | pubmed:meshHeading | pubmed-meshheading:10628903... | lld:pubmed |
| pubmed-article:10628903 | pubmed:meshHeading | pubmed-meshheading:10628903... | lld:pubmed |
| pubmed-article:10628903 | pubmed:meshHeading | pubmed-meshheading:10628903... | lld:pubmed |
| pubmed-article:10628903 | pubmed:meshHeading | pubmed-meshheading:10628903... | lld:pubmed |
| pubmed-article:10628903 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10628903 | pubmed:articleTitle | Acute toxicity profile of maprotiline in the rat. | lld:pubmed |
| pubmed-article:10628903 | pubmed:affiliation | Department of Pharmacology, National University of Ireland, Galway. pipdarcy@hotmail.com | lld:pubmed |
| pubmed-article:10628903 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10628903 | lld:pubmed |
