| pubmed-article:10624961 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10624961 | lifeskim:mentions | umls-concept:C0679729 | lld:lifeskim |
| pubmed-article:10624961 | lifeskim:mentions | umls-concept:C0034143 | lld:lifeskim |
| pubmed-article:10624961 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:10624961 | lifeskim:mentions | umls-concept:C0231435 | lld:lifeskim |
| pubmed-article:10624961 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:10624961 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:10624961 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10624961 | pubmed:dateCreated | 2000-1-27 | lld:pubmed |
| pubmed-article:10624961 | pubmed:abstractText | Endogenous high-affinity Ca2+ buffering and its roles were investigated in mouse cerebellar Purkinje cells with the use of a low-affinity Ca2+ indicator and a high-affinity caged Ca2+ compound. Increases in the cytosolic Ca2+ concentration ([Ca2+]i) were markedly facilitated during repetitive depolarization, resulting in the generation of steep micromolar Ca2+ gradients along dendrites. Such supralinear Ca2+ responses were attributed to the saturation of a large concentration (0.36 mM) of a mobile, high-affinity (dissociation constant, 0.37 microM) Ca2+ buffer with cooperative Ca2+ binding sites, resembling calbindin-D28K, and to an immobile, low-affinity Ca2+ buffer. These data suggest that the high-affinity Ca2+ buffer operates as the neuronal computational element that enables efficient coincidence detection of the Ca2+ signal and that facilitates spatiotemporal integration of the Ca2+ signal at submicromolar [Ca2+]i. | lld:pubmed |
| pubmed-article:10624961 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10624961 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10624961 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10624961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10624961 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10624961 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10624961 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:10624961 | pubmed:author | pubmed-author:MaedaHH | lld:pubmed |
| pubmed-article:10624961 | pubmed:author | pubmed-author:MiyashitaYY | lld:pubmed |
| pubmed-article:10624961 | pubmed:author | pubmed-author:ItoKK | lld:pubmed |
| pubmed-article:10624961 | pubmed:author | pubmed-author:KasaiHH | lld:pubmed |
| pubmed-article:10624961 | pubmed:author | pubmed-author:Ellis-DaviesG... | lld:pubmed |
| pubmed-article:10624961 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10624961 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:10624961 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10624961 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10624961 | pubmed:pagination | 989-1002 | lld:pubmed |
| pubmed-article:10624961 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10624961 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10624961 | pubmed:articleTitle | Supralinear Ca2+ signaling by cooperative and mobile Ca2+ buffering in Purkinje neurons. | lld:pubmed |
| pubmed-article:10624961 | pubmed:affiliation | Department of Physiology, Faculty of Medicine, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:10624961 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10624961 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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