| pubmed-article:10617128 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10617128 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:10617128 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10617128 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:10617128 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:10617128 | lifeskim:mentions | umls-concept:C0035179 | lld:lifeskim |
| pubmed-article:10617128 | lifeskim:mentions | umls-concept:C0011307 | lld:lifeskim |
| pubmed-article:10617128 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:10617128 | lifeskim:mentions | umls-concept:C1550147 | lld:lifeskim |
| pubmed-article:10617128 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:10617128 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10617128 | pubmed:dateCreated | 2000-1-18 | lld:pubmed |
| pubmed-article:10617128 | pubmed:abstractText | The influence of L-DOPA and reserpine on extracellular dopamine (DA) levels in the striatum of intact and dopaminergic denervated rats was studied using the brain microdialysis technique. In intact rats, reserpine (5 mg/kg s.c.) reduced extracellular DA levels to 4% of basal values. L-DOPA (50 mg/kg i.p.) had no effect on extracellular DA levels in reserpine-pretreated rats. In rats with 6-hydroxydopamine-induced lesion of the nigrostriatal dopaminergic system, basal levels of extracellular DA were low but markedly increased by L-DOPA (50 mg/kg i.p.). In 6-hydroxydopamine-lesioned rats, pretreatment with reserpine (5 mg/kg s.c.) diminished L-DOPA (50 mg/kg i.p.)-induced increases in extracellular DA levels to 16% of those obtained in denervated animals not pretreated with reserpine (p<0.01). These results suggest that in the intact striatum, extracellular DA stems mainly from vesicular storage sites and that in the striatum with dopaminergic denervation, a large part of the L-DOPA-derived extracellular DA is also derived from a vesicular pool that is released by an exocytosis mechanism. | lld:pubmed |
| pubmed-article:10617128 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10617128 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617128 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10617128 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617128 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617128 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617128 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617128 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10617128 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10617128 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10617128 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:10617128 | pubmed:author | pubmed-author:TanakaHH | lld:pubmed |
| pubmed-article:10617128 | pubmed:author | pubmed-author:MaedaTT | lld:pubmed |
| pubmed-article:10617128 | pubmed:author | pubmed-author:MatsunagaMM | lld:pubmed |
| pubmed-article:10617128 | pubmed:author | pubmed-author:SudaTT | lld:pubmed |
| pubmed-article:10617128 | pubmed:author | pubmed-author:TomiyamaMM | lld:pubmed |
| pubmed-article:10617128 | pubmed:author | pubmed-author:KannariKK | lld:pubmed |
| pubmed-article:10617128 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10617128 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:10617128 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10617128 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10617128 | pubmed:pagination | 263-9 | lld:pubmed |
| pubmed-article:10617128 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:meshHeading | pubmed-meshheading:10617128... | lld:pubmed |
| pubmed-article:10617128 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10617128 | pubmed:articleTitle | Reserpine pretreatment prevents increases in extracellular striatal dopamine following L-DOPA administration in rats with nigrostriatal denervation. | lld:pubmed |
| pubmed-article:10617128 | pubmed:affiliation | Third Department of Medicine, Hirosaki University School of Medicine, Japan. kkanhki@umin.ac.jp | lld:pubmed |
| pubmed-article:10617128 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10617128 | lld:pubmed |
